SAMPLE PREPARATION, PROCESSING AND ANALYSIS SYSTEM

• Main Authors: WYRICK DAVID W, BELCINSKI, RICHARD, J, VAN GELDER, EZRA, JOVANOVICH STEVAN B, NIELSEN WILLIAM D, EL-SISSI OMAR, RECKNOR, MICHAEL, BOGDAN GREGORY, EBERHART DAVID
• Format: Patent
• Language: Chinese; English
• Published: 19.03.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; TRANSPORTING; VINEGAR; WINE

The invention relates to a sample preparation, processing and analysis system. The present disclosure provides an integrated and automated sample-to-result system that generates a genetic profile within less than two hours starting from a sample comprising biological material. In certain embodiments, the biological material is DNA, and the genetic profile involves determining alleles located at one or more loci (e.g., genetic loci) of the subject, e.g., STR (Short Tandem Repeat) profiles, e.g., STR profiles used in CODIS systems. The system can execute several operations including (a) extraction and separation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification products. These operations may be performed in a system comprising several integrated modules, including an analyte preparation module, a detection and analysis module, and a control module. 本申请涉及样品制备、处理和分析系统。本公开提供集成的且自动化的样品到结果系统，该系统从包含生物材料的样品开始，在不到两小时内生成遗传谱。在