Circulating transcription factor analysis

• Main Authors: PARMART DIDIER FRANCOIS FRANCOIS, HERZOG MATTHIAS, MICALLEF JAMES VINCENT, ECCLESTON, MARK, E
• Format: Patent
• Language: Chinese; English
• Published: 20.10.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; VINEGAR; WINE

The present invention relates to a method for detecting a disease in a subject by minimally invasive bodily fluid testing for detecting circulating chromatin fragments comprising transcription factors and associated DNA sequences as indicators of the presence of a disease, such as cancer, in a subject. The method may include sequencing the associated DNA sequence and/or removing cell-free nucleosomes from the bodily fluid. 本发明涉及通过用于检测循环染色质片段的微创体液测试来检测受试者中的疾病的方法，所述染色质片段包括转录因子和缔合DNA序列作为受试者中疾病存在的指示物，例如癌症。所述方法可以包括对缔合DNA序列测序和/或从体液去除无细胞核小体。