TTK基因及TTK的抑制剂在治疗动脉粥样硬化中的应用

• Format: Patent
• Language: Chinese
• Published: 29.07.2025
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明属于医药领域，提供了一种TTK基因及TTK的抑制剂在治疗动脉粥样硬化中的应用。本发明以APOE-/-TTKWT小鼠及APOE-/-TTKKO小鼠为实验对象，通过高脂饮食诱导获得动脉粥样硬化模型，结果表明与APOE-/-TTKWT小鼠对比，TTK基因缺失的APOE-/-TTKKO小鼠主动脉的斑块面积显著减少。这表明TTK具有促进主动脉斑块形成，促进动脉粥样硬化的作用。针对TTK的上述功能，本发明提出了TTK可作为药物靶标在筛选预防、缓解和/或治疗动脉粥样硬化的药物中的应用以及TTK的抑制剂在制备预防、缓解和/或治疗动脉粥样硬化的药物中的应用。本发明的提出为预防、缓解和/或治疗动脉粥样硬化提供了新的靶点和药物，对阐明动脉粥样硬化发生发展过程中的分子机制，寻找动脉粥样硬化治疗的分子靶点具有重要意义。 The invention belongs to the field of medicines, and provides a TTK gene and application of a TTK inhibitor in treatment of atherosclerosis. An APOE-/-TTKWT mouse and an APOE-/-TTKKO mouse are taken as experimental subjects, an atherosclerosis model is obtained through high fat diet induction, and the result shows that compared with the APOE-/-TTKWT mouse, the plaque area of the aorta of the APOE-/-TTKKO mouse with TTK gene deletion is remarkably reduced. The result shows that TTK has the effects of promoting aortic plaque formation and promoting atherosclerosis. Aiming at the functions of the TTK, the invention provides an application of the TTK as a drug targ