一类多肽蛋白类药物口服吸收促进剂及其制备方法与用途

• Format: Patent
• Language: Chinese
• Published: 27.09.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明属于医药技术领域，公开了一类结构如通式I所示的化合物。本发明通式I所示的化合物符合离子液体的定义。本发明通式I所示的化合物具有口服吸收促进剂的特点，可以减少胃肠道环境和蛋白酶对蛋白和/或多肽类药物的降解，或增加蛋白和/或多肽类药物肠粘膜的通透效果、在胃肠道部位的吸收，或提高多肽蛋白类药物口服给药后的治疗效果。本发明还公开了通式I所示的化合物在作为增加蛋白和/或多肽类药物口服递送的口服吸收促进剂中的应用。#imgabs0# The invention belongs to the technical field of medicines, and discloses a compound with a structure as shown in a general formula I. The compound shown in the general formula I conforms to the definition of ionic liquid. The compound shown in the general formula I has the characteristics of an oral absorption enhancer, and can reduce degradation of a gastrointestinal tract environment and protease to protein and/or polypeptide drugs, or increase the permeation effect of intestinal mucosa of the protein and/or polypeptide drugs and absorption of the protein and/or polypeptide drugs in gastrointestinal tract parts, or improve the treatment effect of the polypeptide and protein drugs after oral administration. The invention also discloses application of the compound as shown in the general formula I