RCOM protein-based carbon monoxide scavengers and formulations for treatment of carbon monoxide poisoning

Methods for rapid removal of carbon monoxide (CO) from CO-binding hemoglobin, myoglobin, and cytochrome c oxidase in CO-poisoned subjects are described. The disclosed therapies involve the use of reasonably designed, modified CO metabolic regulator (RcoM) proteins and pharmaceutical compositions the...

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Main Authors TEJERO BRAVO JESUS, DENT MARK RICHARD, DEMARTINO ANDREW W, ROSE JOHN JOSEPH, GLADWIN MARK T
Format Patent
LanguageChinese
English
Published 31.01.2023
Subjects
AMMONIA
CHEMISTRY
COMPOUNDS THEREOF
CYANOGEN
INORGANIC CHEMISTRY
METALLURGY
NON-METALLIC ELEMENTS
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Methods for rapid removal of carbon monoxide (CO) from CO-binding hemoglobin, myoglobin, and cytochrome c oxidase in CO-poisoned subjects are described. The disclosed therapies involve the use of reasonably designed, modified CO metabolic regulator (RcoM) proteins and pharmaceutical compositions thereof, which scavenge carbon monoxide from poisoned tissues. Recombinant RcoM compositions are infused into blood, which rapidly isolate carbon monoxide in the blood and limit the toxic effects of carbon monoxide on cellular respiration, oxygen delivery and oxygen utilization. 描述了在CO中毒的对象中从结合CO的血红蛋白、肌红蛋白和细胞色素c氧化酶中快速去除一氧化碳(CO)的方法。所公开的疗法涉及使用合理设计的、经修饰的CO代谢调节因子(RcoM)蛋白及其药物组合物，其从中毒的组织中清除一氧化碳。将重组RcoM组合物输注入血液中，它们在血液中快速分离一氧化碳并限制一氧化碳对细胞呼吸、氧输送和氧利用的毒性作用。
Bibliography:Application Number: CN20218034663