Methods of treating cytokine storm syndrome and related diseases

• Main Authors: FU XINYUAN, ZHOU YI, LIU XINYU, LU-FEI CHENGCHEN
• Format: Patent
• Language: Chinese; English
• Published: 16.12.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides methods of treating cytokine storm syndrome and related diseases, including infectious diseases such as COVID-19. Specifically, the present disclosure provides a method of treating cytokine storm syndrome (CSS) in a subject in need thereof, comprising administering to the subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of pimozide and artemisinin and derivatives thereof, or pharmaceutically acceptable salts thereof, or solvates thereof. 本公开提供了治疗细胞因子风暴综合症及相关疾病的方法，包括如COVID-19等传染病。具体来说，本公开提供了一种治疗有需要的受试者的细胞因子风暴综合征(CSS)的方法，包括对有需要的受试者给药治疗有效量的化合物，所述化合物选自匹莫齐特和青蒿素及其衍生物，或其药学可接受的盐，或其溶剂合物。