Use of several negative cells for treatment of sickle cell disease

• Main Authors: SINGH, ALUJIK, KUMAR, REISSNER, JARL
• Format: Patent
• Language: Chinese; English
• Published: 12.08.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

A method of treating or preventing sickle cell disease in a subject in need thereof is disclosed. The method comprises: (a) transplanting a number of immature hematopoietic cells into the subject; and (b) administering to the subject a therapeutically effective amount of an isolated population of a number of non-GVHD-induced anti-third party cells, the isolated population of the number of non-GVHD-induced anti-third party cells comprising a number of cells having a central memory T lymphocyte phenotype, the number of cells is a number of tolerance-inducing cells and is capable of homing to the number of lymph nodes after transplantation. 公开了一种治疗或预防有需要的一受试者的一镰状细胞病的方法。所述方法包括：(a)将数个未成熟造血细胞移植到所述受试者体内；及(b)向所述受试者施用一治疗有效量的数个非GVHD诱导抗第三方细胞的一分离族群，所述数个非GVHD诱导抗第三方细胞的分离族群包括具有一中枢记忆T淋巴细胞表型的数个细胞，所述数个细胞是数个耐受诱导细胞并且能够在移植后归巢至所述数个淋巴结。