ALK inhibitors for treatment of ALK negative cancers and plasma cell mediated diseases

• Main Authors: DRIESEN COEN, BESSY, LAURENT, SCANLANDER STEVEN, GILIBERTO MAURIZIO, BASSI ANDREA, TASKIN KIRILL, HELLEM SJAERSVOLD, F, FARHAN HOOMAN, MONTE LAURENT
• Format: Patent
• Language: Chinese; English
• Published: 12.08.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides a method of treating an ALK-negative/LTK-positive cancer in a subject, comprising administering to the subject a pharmaceutically effective dose of a linear ALK inhibitor. The invention has special application in treatment of multiple myeloma, including proteasome inhibitor drug-resistant multiple myeloma. 本发明提供了治疗对象的ALK阴性/LTK阳性癌症的方法，包括向对象施用药学上有效剂量的线性ALK抑制剂。本发明在治疗多发性骨髓瘤包括蛋白酶体抑制剂耐药的多发性骨髓瘤方面具有特殊用途。