Antibodies against leptin receptor

• Main Authors: YANG GUANG, TAO PINGDONG
• Format: Patent
• Language: Chinese; English
• Published: 22.04.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

The present invention relates to compositions and methods for preventing or treating diseases associated with mutant leptin receptors, leptin deficiency, or leptin dysfunction. The invention also relates to administering an effective amount of an anti-leptin receptor antibody to treat a subject suffering from or susceptible to a disease associated with a mutant leptin receptor, obesity, leptin deficiency, leptin resistance, and/or hypoleptinemia. 本发明涉及预防或治疗与突变瘦素受体、瘦素缺乏或瘦素功能障碍相关的疾病的组合物和方法。本发明还涉及施用有效量的抗瘦素受体抗体，以治疗患有或易患与突变瘦素受体、肥胖、瘦素缺乏、瘦素抵抗和/或低瘦素血症相关的疾病的受试者。