Methods for modulating macrophage activity

• Main Authors: MARTIN, GEORGE, R, YATES CLAYTON, JAYNES JESSE, LOPEZ HENRY WILFRED
• Format: Patent
• Language: Chinese; English
• Published: 18.03.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

Aspects of the present disclosure include methods for modulating macrophage activity. Methods according to certain embodiments include contacting a macrophage with a mannose receptor (CD206) binding agent in a manner sufficient to modulate macrophage activity. Also provided are methods of converting a phenotype of a macrophage from an M2 phenotype to an M1 phenotype. Methods for inhibiting the growth of cells expressing CD206 and methods for treating neoplastic disorders (e.g., cancer) or disorders associated with chronic inflammation in a subject are described. Also provided are immunomodulatory peptides suitable for use in the methods. 本公开的方面包括用于调节巨噬细胞活性的方法。根据某些实施方案的方法包括以足以调节巨噬细胞活性的方式使巨噬细胞与甘露糖受体(CD206)结合剂接触。还提供了将巨噬细胞的表型从M2表型转化为M1表型的方法。描述了用于抑制表达CD206的细胞的生长的方法以及用于治疗受试者的肿瘤性病症(例如，癌症)或与慢性炎症相关的病症的方法。还提供了适用于本方法的免疫调节肽。