Porous rhodium nano-material as well as preparation method and anti-tumor application thereof

• Main Authors: WANG HAIXIANG, MIAO ZHAOHUA, YU YUE
• Format: Patent
• Language: Chinese; English
• Published: 08.02.2022
• Subjects: CASTING; HUMAN NECESSITIES; HYGIENE; MAKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MEDICAL OR VETERINARY SCIENCE; NANOTECHNOLOGY; PERFORMING OPERATIONS; POWDER METALLURGY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; TRANSPORTING; WORKING METALLIC POWDER

The invention discloses a porous rhodium nano-material as well as a preparation method and anti-tumor application thereof. The particle size of the porous rhodium nano-material is 20-200nm, and the pore diameter is 5-20nm. The porous rhodium nano material has excellent photo-thermal conversion performance, can improve the photo-thermal treatment targeting tumor effect, reduce the damage of illumination to tissues, enhance the photo-thermal tumor cell killing effect and improve the photo-thermal treatment effect, and breaks the oxidation-reduction balance in tumor cells by depleting glutathione, so that the tumor cells are killed; the preparation method disclosed by the invention is simple and feasible, is easy to amplify and is used for commercial production, and opens up a new way for popularizing the application of the biological nano material. 本发明公开了一种多孔铑纳米材料及其制备方法与抗肿瘤应用，该多孔铑纳米材料的粒径为20-200nm，孔直径为5-20nm。本发明的多孔铑纳米材料具备优异的光热转化性能，且可提高光热治疗靶向肿瘤效果，降低光照对组织的损伤，增强光热杀伤肿瘤细胞作用，提高光热治疗效果，并通过耗竭谷胱甘肽打破肿瘤细胞内氧化还原平衡，从而杀伤肿瘤细胞；本发