包封的气体或部分真空CT造影材料

• Format: Patent
• Language: Chinese
• Published: 28.07.2023
• Subjects: DIAGNOSIS; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SURGERY

本发明涉及一种肠造影介质制剂，其被配制为用于口服递送至受试者，同时在所述受试者的腹部进行医学成像程序，所述制剂包含：肠造影介质，所述肠造影介质包含一种包封的气体或部分真空颗粒(例如中空硼硅酸盐微球)和水性载体组分的悬浮液，其中所述水性组分是药学上可接受的水性载体，其中，所述颗粒包括限定内部空隙的壳，所述壳由向所述造影介质制剂贡献至少约30亨氏单位(HU)的材料组成或由在所述医学成像程序期间所述造影介质制剂分布于其中的体腔形成。 The present invention provides an encapsulated gas or partial vacuum particle contrast media for use in CT imaging. In an exemplary embodiment, the invention provides an enteric contrast medium formulation. An exemplary formulation comprises, (a) an enteric contrast medium comprising a encapsulated gas or partial vacuum particle suspended in water. Exemplary encapsulated gas or partial vacuum particle has a specific gravity between 0.2 and 1.5. In various embodiments, the encapsulated gas or partial vacuum particle is suspended in aqueous media by an agent compatible with enteric administration of the formulation to a subject in need of such administration. In an exemplary embodiment, the contrast material is incorporated into a pharmaceutically acceptable carrier in which the material is suspende