PIC1 VARIANTS WITH IMPROVED SOLUBILITY AND METHODS OF USING THE SAME

• Main Authors: CUNNION KENJI, KRISHNA NEEL K
• Format: Patent
• Language: Chinese; English
• Published: 01.10.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A method of improving the lifespan of transfused platelets is described. The method may be useful for patients with alloimmunozation who are refractory to transfused platelets. A method of treating delayed hemolytic transfusion reaction is also described. Also described are PIC1 peptide variants with improved solubility and activity. 本发明描述了一种提高输注的血小板的寿命的方法。所述方法可用于对输注的血小板不应的同种免疫患者。本发明还描述了一种治疗迟发性溶血性输血反应的方法。本发明还描述了具有改进的溶解性和活性的PIC1肽变体。