TRPML1特异性小分子抑制剂ML-SI3的应用

• Format: Patent
• Language: Chinese
• Published: 29.07.2022
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明公开了TRPML1特异性小分子抑制剂ML－SI3在预防和治疗急性心肌缺血再灌注损伤药物方面的应用，且在预防和治疗急性心肌缺血再灌注损伤时，所述的TRPML1特异性小分子抑制剂ML－SI3的有效剂量为0.15mg/kg－1.5mg/kg。本发明的有益效果为：本发明所述TRPML1特异性小分子抑制剂ML－SI3的新用途，为急性心肌缺血再灌注损伤的预防和治疗提供了新的药物，具有良好的市场价值和临床应用前景。 The invention discloses an application of a TRPML1 specific small-molecule inhibitor ML-SI3 in the aspect of medicines for preventing and treating acute myocardial ischemia reperfusion injury, and when the TRPML1 specific small-molecule inhibitor ML-SI3 is used for preventing and treating the acute myocardial ischemia reperfusion injury, the effective dose of the TRPML1 specific small-molecule inhibitor ML-SI3 is 0.15 mg/kg to 1.5 mg/kg. The application of the TRPML1 specific small-molecule inhibitor ML-SI3 has the beneficial effects that the new application of the TRPML1 specific small-molecule inhibitor ML-SI3 provides a new medicine for preventing and treating acute myocardial ischemia reperfusion injury, and has good market value and clinical application prospect.