具有异源刺突蛋白的H52 IBV疫苗

• Format: Patent
• Language: Chinese
• Published: 25.04.2025
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

本发明涉及H52IBV(传染性支气管炎病毒)，其编码异源S(刺突)蛋白或其片段。进一步地，本发明涉及一种免疫原性组合物，其包含所述编码异源S(刺突)蛋白或其片段的H52IBV。再者，本发明涉及用于免疫对象的方法，包括给所述对象施用本发明的免疫原性组合物。此外，本发明涉及在有需要的对象中治疗或预防由IBV引起的临床体征的方法，所述方法包括给对象施用治疗有效量的根据本发明的免疫原性组合物。 The present invention relates i.a. to an H52 IBV (infectious bronchitis virus) encoding for a heterologous S (spike) protein or fragment thereof. Further, the present invention relates to an immunogenic composition comprising said H52 IBV encoding for a heterologous S (spike) protein or fragment thereof. Furthermore, the present invention relates to methods for immunizing a subject comprising administering to such subject the immunogenic composition of the present invention. Moreover, the present invention relates to methods of treating or preventing clinical signs caused by IBV in a subject of need, the method comprising administering to the subject a therapeutically effective amount of an immunogenic composition according to the present invention.