METHODS AND COMPOSITIONS FOR THE EXPANSION AND USE OF ALLOGENEIC GAMMA/DELTA-T CELLS

• Main Author: LOPEZ RICHARD D
• Format: Patent
• Language: Chinese; English
• Published: 08.06.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Methods for treating cancer in a subject are provided herein. Such methods comprise administration of donor-derived allogeneic gamma/delta-T cells to a subject. In such methods, at least one lymphodepletion treatment or a Hematopoietic Stem Cell (HSC) transplant is administered to the subject, followed by the subsequent administration of donor-derived allogeneic gamma/delta-T cells. The methods also comprise expanding the donor-derived allogeneic gamma/delta-T cells ex vivo prior to administration to the subject. Such methods comprise exposing donor-derived allogeneic gamma/delta-T cells to one or more gamma/delta-T cell expansion compounds. Such a therapy induces an antitumor response in the subject. 本文提供了用于治疗受试者的癌症的方法。此类方法包括向受试者施用供体来源的同种异体γδ-T细胞(gamma/delta-T细胞)。在这样的方法中，向受试者施用淋巴耗竭处理或造血干细胞(HSC)移植物中的至少一种，然后是随后施用供体来源的同种异体γδ-T细胞。该方法还包括在施用给受试者之前离体扩增供体来源的同种异体γδ-T细胞。这样的方法包括将供体来源的同种异体γδ-T细胞暴露于一种或多种γδ-T细胞扩增化合物。这种疗法在受试者中诱导抗肿瘤应答。