COMPOSITIONS AND METHODS FOR TREATING IMMUNE THROMBOCYTOPENIA

• Main Authors: DE HAARD HANS, LEUPIN NICOLAS, ULRICHTS PETER, COUSIN THIERRY, DREIER TORSTEN, VAN BRAGT TONKE
• Format: Patent
• Language: Chinese; English
• Published: 16.03.2021
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

A method is disclosed for the treatment of human subjects diagnosed with immune thrombocytopenia (ITP). The method comprises administering to a human subject a human neonatal Fc receptor (hFcRn) antagonist, optionally in combination with standard-of-care ITP treatment. In certain embodiments, the hFcRn antagonist is efgartigimod (ARGX-113). Standard-of-care ITP treatment may comprise administration of corticosteroids, immunosuppressants, and/or thrombopoietin receptor (TPO-R) agonists. 公开了一种用于治疗被诊断患有免疫性血小板减少症(ITP)的人类受试者的方法。所述方法包括向人类受试者施用人类新生儿Fc受体(hFcRn)拮抗剂，任选地与护理标准ITP治疗组合施用。在某些实施方案中，所述hFcRn拮抗剂是依加替莫德(ARGX-113)。护理标准ITP治疗可以包括施用皮质类固醇、免疫抑制剂和/或血小板生成素受体(TPO-R)激动剂。