Lactobacillus casei zhang and application thereof in preventing and treating chronic gastroenteritis

• Main Authors: LIU XIAOJUN, QIMUGESUDU, MA JIE, ZHANG LINGYU, ZHANG JIANJUN, YANG HUIJUAN
• Format: Patent
• Language: Chinese; English
• Published: 17.07.2020
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; FODDER; FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; PROCESSES USING MICROORGANISMS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES; VINEGAR; WINE

The invention discloses lactobacillus casei zhang and an application thereof in preventing and treating the chronic gastroenteritis. According to the invention, lactic acid bacteria separated from traditional fermented dairy products-koumiss are used as target florae; the potential probiotics Lactobacillus casei zhang with relatively strong survivability is screened in an intestinal tract environment by an in-vitro acid resistance test and a cholate tolerance test; and animal experiments prove that the traditional Chinese medicine composition has the functions of regulating intestinal flora, improving body immunity, preventing, treating and repairing the chronic gastroenteritis and relieving diarrhea and abdominal discomfort. 本申请公开了一株干酪乳杆菌及其在防止慢性胃肠炎中的应用。本申请以传统发酵乳制品-酸马奶中分离的乳酸菌为目标菌群，经体外耐酸性试验和胆盐耐受性试验筛选出在肠道环境中生存能力较强的潜在益生菌干酪乳杆菌(Lactobacillus casei zhang)，并通过动物实验证实了其具有调节肠道菌群，提高机体免疫力，具有防治和修复慢性胃肠炎，缓解腹泻及腹部不适的功能。