Method of treating or preventing ischemia-reperfusion injury

• Main Authors: BAZ MORELLI ADRIANA, VIKSTROM INGELA, PEARSE MARTIN
• Format: Patent
• Language: Chinese; English
• Published: 14.07.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure relates to a method for preventing or treating ischemia-reperfusion injury in a subject the method comprising administering a compound that inhibits granulocyte colony stimulating factor (G-CSF) signaling. In some examples, the ischemia-reperfusion injury is due to or associated with tissue or organ transplantation. In some examples, the compound is an antibody. 本公开涉及用于防止或治疗受试者的缺血-再灌注损伤的方法，所述方法包括施用抑制粒细胞集落刺激因子(G-CSF)信号传导的化合物。在一些示例中，缺血-再灌注损伤是由于组织或器官移植或与组织或器官移植相关。在一些示例中，所述化合物是抗体。