DIHYDROQUINOLINONES

The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. Present compounds are thus useful for the treatmen...

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Bibliographic Details
Main Authors NORCROSS ROGER, KUSZNIR ERIC ANDRE, WICHERT MORENO ATTILIO, BRITSCHGI ADRIAN, DEY FABIAN, GOERGLER ANNICK
Format Patent
LanguageChinese
English
Published 12.06.2020
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention provides compounds which bind to the ubiquitously expressed E3 ligase protein cereblon (CRBN) and alter the substrate specificity of the CRBN E3 ubiquitin ligase complex, resulting in breakdown of intrinsic downstream proteins. Present compounds are thus useful for the treatment of various cancers. 本发明提供了与泛表达的E3连接酶蛋白cereblon(CRBN)结合并改变CRBN E3泛素连接酶复合物的底物特异性从而导致内在下游蛋白分解的化合物。因此，本发明化合物可用于治疗各种癌症。
Bibliography:Application Number: CN20188069759