一种对抗结核药物诱导的肝损伤具有修复和预防作用的枸杞糖肽制备方法

本发明公开了一种对抗结核药物诱导的肝损伤具有修复和预防作用的枸杞糖肽制备方法，该方法是将枸杞子粉碎、过筛、亚临界脱脂、高速剪切低温破壁水提、乙醇沉淀、热水复溶、高速离心、微滤膜纯化、纳滤膜浓缩、三氯乙酸脱蛋白、活性炭脱色、冷冻干燥，得到具有预防和修复抗结核药物诱导的肝损伤功能枸杞糖肽。主要组分分析表明该枸杞糖肽的分子量为10kD~5kD，多糖含量≥85%，糖醛酸含量≥10%。活性实验表明，本发明该枸杞糖肽能够增强肝细胞活力，显著下调异烟肼、利福平导致的谷丙转氨酶活性和谷草转氨酶水平，对抗结核药物利福平、异烟肼引起的肝损伤具有较好的预防和修复作用，可作为有效成分，用于保健食品和药物制剂的制备。...

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Bibliographic Details
Format Patent
LanguageChinese
Published 07.04.2023
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明公开了一种对抗结核药物诱导的肝损伤具有修复和预防作用的枸杞糖肽制备方法，该方法是将枸杞子粉碎、过筛、亚临界脱脂、高速剪切低温破壁水提、乙醇沉淀、热水复溶、高速离心、微滤膜纯化、纳滤膜浓缩、三氯乙酸脱蛋白、活性炭脱色、冷冻干燥，得到具有预防和修复抗结核药物诱导的肝损伤功能枸杞糖肽。主要组分分析表明该枸杞糖肽的分子量为10kD~5kD，多糖含量≥85%，糖醛酸含量≥10%。活性实验表明，本发明该枸杞糖肽能够增强肝细胞活力，显著下调异烟肼、利福平导致的谷丙转氨酶活性和谷草转氨酶水平，对抗结核药物利福平、异烟肼引起的肝损伤具有较好的预防和修复作用，可作为有效成分，用于保健食品和药物制剂的制备。 The invention discloses a preparation method of lycium barbarum glycopeptide with effect of repairing and preventing liver injury induced by anti-tuberculosis drugs. The method subjects lycium barbarum fruits to crushing, sieving, subcritical degreasing, high-speed shearing and low-temperature wall-breaking water extraction, ethanol precipitation, hot water redissolution, high-speed centrifugation, microfiltration membrane purification, nanofiltration membrane concentration, trichloroacetic acid deproteinization, active carbon decolorization and freeze drying so as to obtain the lycium barbarum glycopeptide with effect of repairing and preventing liver injury induced by anti-tuberculosis drugs. The main component a
Bibliography:Application Number: CN201910496925