Isotopically modified components and therapeutic uses thereof

• Main Author: SHCHEPINOV MIKHAIL S
• Format: Patent
• Language: Chinese; English
• Published: 23.08.2019
• Subjects: APPARATUS THEREFOR; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Methods are provided of identifying a subject having impaired aldehyde dehydrogenase activity; and administering to the subject a compound comprising an isotopicaliy-modified polyunsaturated fatty acid, an isotopicaliy-modified polyunsaturated fatty acid ester, an isotopicaliy-modified polyunsaturated fatty acid thioester, an isotopicaliy-modified polyunsaturated fatty acid amide, a polyunsaturated fatty acid mimetic, or an isotopicaliy-modified polyunsaturated fatty acid pro-drug, the compound having an isotopic modification that reduces oxidation of the compound, thereby reducing productionin the subject of substrate for aldehyde dehydrogenase. Some aspects provide coadministering an isotopicaliy-modified polyunsaturated fatty acid and an oxylipin. 提供了鉴定具有受损的醛脱氢酶活性的受试者；以及向所述受试者施用包含以下物质的化合物的方法：同位素修饰的多不饱和脂肪酸、同位素修饰的多不饱和脂肪酸酯、同位素修饰的多不饱和脂肪酸硫酯、同位素修饰的多不饱和脂肪酸酰胺、多不饱和脂肪酸模拟物、或同位素修饰的多不饱和脂肪酸前药，所述化合物具有同位素修饰，所述修饰减少所述化合物的氧化，从而减少所述受试者中醛脱氢酶的底物的产生。一些方面提供了共同施用同位素修饰的多不饱和脂肪酸和氧脂素。