Methods for treating conditions associated with MASP-2 dependent complement activation

• Main Authors: DUDLER TOM, DEMOPULOS GREGORY A, SCHWAEBLE HANS-WILHELM
• Format: Patent
• Language: Chinese; English
• Published: 02.08.2019
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, with the compositions comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier. 在一个方面，本发明提供了在有生命受试者中抑制MASP-2依赖性补体活化的影响的方法。本发明包括将有效抑制MASP-2依赖性补体活化的量的MASP-2抑制剂施用于需要其的受试者的步骤。在一些实施方案中，MASP-2抑制剂抑制与MASP-2介导的替代补体途径活化相关的细胞损伤，而使免疫系统的经典(C1q依赖性)途径组分保持完整。在另一个方面，本发明提供了用于抑制凝集素依赖性补体活化的影响的组合物，所述组合物包含治