用于预防、减轻和/或治疗痴呆的系统和方法

• Format: Patent
• Language: Chinese
• Published: 12.08.2022
• Subjects: ELECTROTHERAPY; HUMAN NECESSITIES; HYGIENE; MAGNETOTHERAPY; MEDICAL OR VETERINARY SCIENCE; RADIATION THERAPY; ULTRASOUND THERAPY

本公开提供用于通过使用例如在体内同步活化受试者的特定细胞类型(例如，快闪-小清蛋白(FS-PV)免疫反应性中间神经元)和/或大脑区域(例如，感觉皮层和/或海马体)的频率(例如，约40Hz)下发射刺激(例如，光、声音和/或触觉)的刺激发射装置在所述受试者的所述大脑中诱导同步γ振荡来预防、降低和治疗所述受试者中的淀粉样蛋白-β(Aβ)肽、C末端片段-β(β-CTF)、β-分泌酶(BACE1)、γ-分泌酶、神经炎症和/或痴呆(例如，阿尔茨海默氏病或年龄相关衰退)中的至少一种的水平或变化中的至少一种的系统和方法。 The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (Aβ) peptide, C-terminal fragment-β (β-CTF), β-secretase (BACE1), γ-secretase, neuroinflammation, and/or dementia (e.g., Alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 Hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (FS-PV) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.