具有人源化淋巴细胞活化基因3的非人动物

本发明提供了非人动物，以及用于制备和使用所述非人动物的方法和组合物，其中所述非人动物包含人源化的淋巴细胞活化基因3(Lag3)。在一些实施方案中，所述非人动物可以描述为具有对内源性Lag3基因座的遗传修饰，使得所述非人动物表达包含人部分和内源性部分(例如，非人部分)的Lag3多肽。 Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Lympho...

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Bibliographic Details
Format Patent
LanguageChinese
Published 08.10.2021
Subjects
AGRICULTURE
ANIMAL HUSBANDRY
CARE OF BIRDS, FISHES, INSECTS
CHEMISTRY
FISHING
FORESTRY
HUMAN NECESSITIES
HUNTING
METALLURGY
NEW BREEDS OF ANIMALS
ORGANIC CHEMISTRY
PEPTIDES
REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR
TRAPPING
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Summary:本发明提供了非人动物，以及用于制备和使用所述非人动物的方法和组合物，其中所述非人动物包含人源化的淋巴细胞活化基因3(Lag3)。在一些实施方案中，所述非人动物可以描述为具有对内源性Lag3基因座的遗传修饰，使得所述非人动物表达包含人部分和内源性部分(例如，非人部分)的Lag3多肽。 Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Lymphocyte activation gene 3 (Lag3). The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Lag3 locus so that the non-human animals express a Lag3 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
Bibliography:Application Number: CN20168067496