紫外线吸收聚合物染料及其使用方法

• Format: Patent
• Language: Chinese
• Published: 30.07.2021
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEASURING; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; PHYSICS; TESTING; THEIR PREPARATION OR CHEMICAL WORKING-UP

提供了具有紫外线吸收最大值的水溶性集光多发色团。在一些实施例中，多发色团包括如下的共轭链段，其包括稠合的6-5-6三环共聚单体和UV吸光度修饰共聚单体。多发色团可以包括在其能量接收附近与多发色团共价连接的受体发色团。在一些实施例中，特异性结合成员与多发色团共价连接。还提供了针对靶分析物的存在对样品进行评估的方法和使用包括集光多发色团的组合物标记靶分子的方法。还提供了用于实践主题方法的试剂盒和系统。 Water soluble light harvesting multichromophores that have an ultraviolet absorption maximum are provided. In some embodiments, the multichromophores include a conjugated segment including a fused 6-5-6 tricyclic co-monomer and a UV absorbance-modifying co-monomer. The multichromophores may include an acceptor chromophore covalently linked to the multichromophore in energy-receiving proximity therewith. In some embodiments, a specific binding member is covalently linked to the multichromophore. Also provided are methods of evaluating a sample for the presence of a target analyte and methods of labelling a target molecule using compositions including the light harvesting multichromophores. Kits and systems for practicing the subject methods are also provided.