G蛋白信号调节因子6及其抑制剂在治疗脂肪肝和Ⅱ型糖尿病中的功能和应用

本发明公开一种RGS6基因在脂肪肝糖尿病疾病中的功能和应用。以RGS6基因敲除小鼠和野生型C57小鼠为实验对象，通过高脂饮食诱导的肥胖小鼠模型，结果表明与野生型C57小鼠对比，RGS6基因敲除小鼠体重减轻，空腹血糖水平低于对照组WT小鼠，肝功能明显优于WT小鼠。通过腹腔注射葡萄糖耐量实验发现RGS6基因敲除小鼠对葡萄糖的耐受能力明显改善。从小鼠肝脏大体外观、肝脏重量及肝脏/体重比以及肝功能相关酶活性测定结果均说明高脂饮食组RGS6-KO小鼠脂肪肝病变明显减轻，脂质蓄积显著减少。因此，RGS6可作为筛选治疗脂肪肝和/或II型糖尿病的药物靶标，其抑制剂可用于制备治疗脂肪肝和/或II型糖尿病的药物。...

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Bibliographic Details
Format Patent
LanguageChinese
Published 08.11.2019
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:本发明公开一种RGS6基因在脂肪肝糖尿病疾病中的功能和应用。以RGS6基因敲除小鼠和野生型C57小鼠为实验对象，通过高脂饮食诱导的肥胖小鼠模型，结果表明与野生型C57小鼠对比，RGS6基因敲除小鼠体重减轻，空腹血糖水平低于对照组WT小鼠，肝功能明显优于WT小鼠。通过腹腔注射葡萄糖耐量实验发现RGS6基因敲除小鼠对葡萄糖的耐受能力明显改善。从小鼠肝脏大体外观、肝脏重量及肝脏/体重比以及肝功能相关酶活性测定结果均说明高脂饮食组RGS6-KO小鼠脂肪肝病变明显减轻，脂质蓄积显著减少。因此，RGS6可作为筛选治疗脂肪肝和/或II型糖尿病的药物靶标，其抑制剂可用于制备治疗脂肪肝和/或II型糖尿病的药物。 The invention discloses a function and an application of an RGS6 (regulator of G protein signaling 6) gen in treatment of fatty liver and diabetes mellitus diseases. An RGS6 gene knockout mouse and a wild type C57 mouse are taken as experimental subjects, by means of a high-fat DIO (diet induced obesity) mouse model, a result shows that compared with the wild type C57 mouse, the weight of the RGS6 gene knockout mouse is reduced, the fasting blood-glucose level is lower than that of the WT mouse in a control group, and the liver function is obviously better than that of the WT mouse. An IPGTT (intraperitoneal glucose tolerance test) shows that the glucose tolerance ability of the RGS6 gene knockout mouse is improve
Bibliography:Application Number: CN201610888108