Method for preparing sodium-glucose co-transport enzyme inhibitor intermediate through utilization of micro-reactor

• Main Authors: XIONG ZHIGANG, ZHANG XINI, ZI CHUNPENG
• Format: Patent
• Language: Chinese; English
• Published: 04.01.2017
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; DERIVATIVES THEREOF; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; NUCLEIC ACIDS; NUCLEOSIDES; NUCLEOTIDES; ORGANIC CHEMISTRY; SUGARS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

The invention discloses a method for preparing a sodium-glucose co-transport enzyme inhibitor intermediate through utilization of a micro-reactor. The method comprises: mixing a solution formed from a compound III and an organic solvent with a metal organic reagent in a micro-reactor unit (L) through material pipes, and allowing the mixed solution to flow to a micro-reactor unit (H) through (L); mixing a solution formed from a compound II and an organic solvent with the solution obtained in the first step in the micro-reactor unit (H) at a pre-set temperature (T2) through a material pipe, allowing the mixed solution to pass through the micro-reactor unit (H) and to flow out from an outlet after a reaction is over; post-treating the reaction liquid flowing out of the outlet to obtain a target product, which is sodium-glucose co-transport enzyme inhibitor intermediate I. The intermediate I is prepared through the micro-reactor, and the problem in heat release of such reaction is solved. The safety of the reacti