种不对称合成天然产物(-)-Euscapholide异构体的新方法

• Format: Patent
• Language: Chinese
• Published: 24.11.2017
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

本发明涉及种不对称合成天然产物(-)-Euscapholide异构体的新方法。以(R)-3-羟基丁酸甲酯为起始原料，经过对甲氧基苄基保护，二异丁基氢化铝还原，Mukaiyama羟醛反应，硼氢化钠还原，酸性下关环，羟基消除，去保护等过程完成了对目标分子1的不对称全合成。该合成路线设计新颖合理，原料价廉易得，操作工艺简便，反应条件温和，高效地完成了具有两个手性中心的Euscapholide个异构体的不对称全合成，产物构型单。