种倍半萜类化合物及其制备方法与应用

• Format: Patent
• Language: Chinese
• Published: 05.04.2017
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

本发明公开了种倍半萜类化合物及其制备方法与应用，所述的倍半萜类化合物是以烟草叶片为原料，经浸膏提取、硅胶柱层析、超临界流体色谱分离得到的，该化合物分子式为CHO，命名为烟草倍半萜-G，具有下述结构式：。所述的制备方法是以烟草叶片为原料，经浸膏提取、硅胶柱层析、超临界流体色谱分离获得。本发明的应用为所述的倍半萜类化合物在制备抗轮状病毒药物中的应用。本发明化合物结构简单活性较好，可作为抗轮状病毒药物研发的先导性化合物用于抗轮状病毒药物制剂研发。 The invention discloses sesquiterpenoids, and a preparation method and application thereof. The sesquiterpenoids are prepared by carrying out extract leaching, silica gel column chromatography and supercritical fluid chromatographic separation on the raw material tobacco leaf. The molecular formula of the compounds is C16H20O3, the name is tobacco sesquiterpenoid-G, and the structural formula is disclosed in the specification. The preparation method comprises the following steps: by using tobacco leaf as the raw material, carrying out extract leaching, silica gel column chromatography and supercritical fluid chromatographic separation. The invention also discloses application of the sesquiterpenoids in preparing anti-rotavirus drugs. The compounds have the advantages of simple structure and