用于龋齿的替代疗法

• Format: Patent
• Language: Chinese
• Published: 19.10.2018
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; TRAPPING

本发明提供可用于改善口腔健康的重组变形链球菌菌株。本发明的个实施方案提供在易患龋齿的宿主中降低龋齿的发生率或严重性的方法，该方法包括口服给予宿主有效量的本发明分离的重组变形链球菌菌株，用于替代宿主口腔中的引起龋齿的变形链球菌宿主菌株。分离的重组变形链球菌菌株10可被包含在漱口剂、牙膏、口香糖、牙线、咀嚼片、食品或饮料中。 The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of MU1140 wherein the amino acid at position (1) is changed to Gly, the amino acid at position (4) is changed to an Ala, or the amino acid at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.