用于局部麻醉和/或疼痛缓解的含有萃取溶剂的挥发性麻醉剂组合物

• Format: Patent
• Language: Chinese
• Published: 13.10.2017
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

本发明通过传送(例如鞘内或硬膜外传送)溶解于溶液中的挥发性麻醉剂来减轻有此需要的患者疼痛的方法，该溶液包括萃取溶剂，例如，DMSO或NMP，麻醉剂的含量能有效减轻疼痛。可以治疗慢性或急性疼痛，或麻醉剂可以作为区域性麻醉剂传送给患者，以在外科手术前使患者的部分麻醉。在特定的实施方案中，可以使用异氟烷、氟烷、恩氟烷、七氟醚、地氟醚、甲氧氟烷或其混合物。考虑了包括次施用、连续和/或周期性施用的给药方案。 The present invention provides methods for reducing pain in a subject in need of such pain reduction by delivering, e.g., intrathecally or epidurally, a volatile anesthetic dissolved in a solution comprising an extractive solvent, e.g., DMSO or NMP, in an amount effective to reduce pain. Chronic or acute pain may be treated, or the anesthetic may be delivered as a regional anesthesia to a subject to anesthetize a portion the subject prior to a surgery, hi certain embodiments, isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, or mixtures thereof may be used. Dosing regimens including a one-time administration, continuous and/or periodic administration are contemplated.