DIGITAL TOPOLOGICAL ANALYSIS OF TRABECULAR BONE MR IMAGES AND PREDICTION OF OSTEOPOROSIS FRACTURES

The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal r...

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Bibliographic Details
Main Authors WEHRLI, FELIX W, GOMBERG, BRYAN R, SAHA, PUNAM K
Format Patent
LanguageEnglish
French
Published 12.10.2002
Edition7
Subjects
CALCULATING
COMPUTING
COUNTING
DIAGNOSIS
HUMAN NECESSITIES
HYGIENE
IDENTIFICATION
IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
MEDICAL OR VETERINARY SCIENCE
PHYSICS
SURGERY
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Summary:The invention provides method, system and device for determining trabecular bone structure and strength by digital topological analysis, and offers, for the first time, a demonstration of superior associations between vertebral deformity and a number of architectural indices measured in the distal radius, thus permitting reliabl e and noninvasive detection and determination of the pathogenesis of osteoporosis. A preferred embodiment provides imaging in three dimension of a region of trabecular bone, after which the 3D image is converted into a skeletonized surface representation. Digital topological analysis is applied to the converted image, and each image voxel is identified and classified as a curve, a surface, or a junction; and then associated with microarchitectural indices of trabecular bone to quantitatively characterize the trabecular bone network. The invention is applicable in vivo, particularly on human subjects, or ex vivo.
Bibliography:Application Number: CA20022381693