Pharmaceutical composition for otic administration

Provided is a pharmaceutical composition that can be otically administered without a complicated procedure, and that has the function of retaining and gradually releasing a medication within the ear. The pharmaceutical composition for otic administration contains one or more types of medication and...

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Main Authors NAGAKURA, Akira, SHIMADA, Ken, MATSUDA, Takaya, OSADA, Mari, YOSHIDA, Takatsune, KOJIMA, Hiroyuki
Format Patent
LanguageEnglish
Published 10.03.2022
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Summary:Provided is a pharmaceutical composition that can be otically administered without a complicated procedure, and that has the function of retaining and gradually releasing a medication within the ear. The pharmaceutical composition for otic administration contains one or more types of medication and a polymer, and has complex viscosity properties wherein, when the complex viscosity of the pharmaceutical composition is measured using a rheometer under conditions of 5% shear strain and 50 rad/sec angular frequency while heating the temperature from 25°C to 37°C at a heating rate of 1°C/10 sec, the complex viscosity is less than 1,650 mPa·s when at 25°C and is 1,650 mPa·s to 100,000 mPa·s, inclusive, at 10 minutes after reaching 37°C.
Bibliography:Application Number: AU20200319755