Impact of virtual and augmented reality based on intraoperative MRI and functional neuronavigation in glioma surgery involving eloquent areas: a Prospective controlled study

• Published in: World neurosurgery
• Main Authors: Sun, Guo-chen, MD, Wang, Fei, MD, Chen, Xiao-lei, MD, Yu, Xin-guang, MD, PhD, Ma, Xiao-dong, MD, PhD, Zhou, Ding-biao, MD, PhD, Zhu, Ru-yuan, MD, Xu, Bai-nan, MD, PhD
• Format: Journal Article
• Language: English
• Published: 2016
• Subjects: Neurosurgery; virtual reality; DTT; High grade glioma; augmented reality; HGG; LGG; functional neuronavigation; Diffusion tensor Imaging; AQ; AR; Aphasia quotient; DTI; Intraoperative MRI; Low grade glioma; Diffusion tensor tractography; VR
• ISSN: 1878-8750
• DOI: 10.1016/j.wneu.2016.07.107

Abstract Background The utility of virtual and augmented reality based on functional neuronavigation and intraoperative magnetic resonance imaging (MRI) for glioma surgery has not been previously investigated. Methods The study population consisted of 79 glioma patients and 55 control subjects. Preoperatively, the lesion and related eloquent structures were visualized by diffusion tensor tractography and blood oxygen level-dependent-functional MRI. Intraoperatively, microscope-based functional neuronavigation was used to integrate the reconstructed eloquent structure and the real head and brain, which enabled safe resection of the lesion. Intraoperative MRI was used to verify brain shift during the surgical process and provided quality control during surgery. The control group underwent surgery guided by anatomical neuronavigation. Results Virtual and augmented reality protocols based on functional neuronavigation and intraoperative MRI provided useful information for performing tailored and optimized surgery. Complete resection was achieved in 55 of 79 (69.6%) glioma patients and 20 of 55 (36.4%) control subjects, with average resection rates of 95.2% ± 8.5% and 84.9% ± 15.7%, respectively. Both the complete resection rate and average extent of resection differed significantly between the two groups (P < 0.01). Postoperatively, the rate of preservation of neural functions (motor, visual field, and language) was lower in controls than in glioma patients at 2 weeks and 3 months (P < 0.01). Conclusion Combining virtual and augmented reality based on functional neuronavigation and intraoperative MRI can facilitate resection of gliomas involving eloquent areas.