COMPARATIVE EVALUATION OF INFLAMMATORY RESPONSE IN DIFFERENT TYPES OF ANESTHESIA FOR COLON CANCERSURGERY

• Published in: Медицина в Кузбассе Vol. 15; no. 4; pp. 36 - 41
• Main Authors: Андрей Олегович Соловьев, Владимир Терентьевич Долгих, Олег Владимирович Леонов, Ольга Николаевна Новичкова
• Format: Journal Article
• Language: Russian
• Published: The Publishing House Medicine and Enlightenment 01.12.2016
• Subjects: воспаление; местная инфильтрационная анестезия; мультимодальная анестезия-аналгезия; рак толстой кишки; хирургический стресс
• ISSN: 1819-0901

Objective – to evaluate the inflammatory response within the first 24 hours postoperative period in patients who underwent resection surgery for colon cancer under different types of anesthesia. Methods: laboratory, statistics. Results. Levels of interleukin 6, 10, C-reactive protein in the blood of patients operated on for colon cancer under multicomponent multimodal anesthesia, analgesia and superficial sympathetic blockade in the first 24 postoperative hours are higher than in patients operated on under inhalation-intravenous anesthesia and systemic pain relief after the surgery. Levels of interleukin 6, 10, C-reactive protein in the blood of patients operated on for colon cancer under multicomponent multimodal anesthesia, analgesia and superficial sympathetic blockade, supplemented with local infiltration anesthesia, are lower than those of patients operated under the same type of anesthesia-analgesia, but without the local infiltration anesthesia. Conclusions. Superficial sympathetic blockade enhances and local infiltration anesthesia reduces the inflammatory response early after the resection surgery for colon cancer, keeping all advantages of multimodal analgesia-anesthesia as an effective means of protection against surgical stress.