Synthesis of 7-chloro-2-oxoheptanoic acid from Grignard reagent(格氏法合成7-氯-2-氧代庚酸)

研究了合成西司他丁（一种肾脱氢二肽酶抑制剂）的中间体7-氯-2-氧代庚酸的新工艺.以1-溴-5-氯-戊烷为起始原料，制成单格氏试剂后与草酸二乙酯加成生成7-氯-2-氧代庚酸乙酯，酯水解制得7-氯-2-氧代庚酸.工艺总收率达46%，产品经质谱证实结构正确....

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Published inZhejiang da xue xue bao. Journal of Zhejiang University. Sciences edition. Li xue ban Vol. 33; no. 2; pp. 209 - 210
Main Authors SHIXiao-hua(石晓华), CHENXin-zhi(陈新志)
Format Journal Article
LanguageChinese
Published Zhejiang University Press 01.03.2006
Subjects
7-氯-2-氧代庚酸
格氏法
西司他丁
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ISSN1008-9497

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Summary:研究了合成西司他丁（一种肾脱氢二肽酶抑制剂）的中间体7-氯-2-氧代庚酸的新工艺.以1-溴-5-氯-戊烷为起始原料，制成单格氏试剂后与草酸二乙酯加成生成7-氯-2-氧代庚酸乙酯，酯水解制得7-氯-2-氧代庚酸.工艺总收率达46%，产品经质谱证实结构正确.
ISSN:1008-9497