Association between DPM1 gene single nucleotide polymorphism and Henoch-Schönlein purpura in children

• Published in: 精准医学杂志 Vol. 40; no. 1; pp. 55 - 59
• Main Author: GAO Xin, ZHANG Qiuye, CHANG Hong, BAI Cui, WANG Dahai, SHAO Leping, LIN Yi
• Format: Journal Article
• Language: Chinese
• Published: Editorial Office of Journal of Precision Medicine 01.02.2025
• Subjects: iga vasculitis|mannosyltransferases|polymorphism, single nucleotide|genotype|alleles|gene frequency|child
• ISSN: 2096-529X
• DOI: 10.13362/j.jpmed.202540022

Objective To investigate the association between DPM1 gene single nucleotide polymorphism and Henoch-Schönlein purpura in children. Methods A total of 156 children with Henoch-Schönlein purpura who were diagnosed and treated in The Affiliated Hospital of Qingdao University from April 2021 to March 2022 were enrolled as case group, and 152 healthy children who underwent physical examination during the same period of time were enrolled as control group. According to the presence or absence of the symptoms of abdominal pain and joint pain, the children were divided into abdominal pain group, non-abdominal pain group, joint pain group, and non-joint pain group; according to whether a child was comorbid with purpura nephritis, they were divided into purpura nephritis group and non-purpura nephritis group. Related clinical data were collected from each group; whole blood DNA was extracted from the peripheral blood of subjects, and the iMLDRTM multiplex SNP typing technique was used to determine the genotype of the