DOES USING EDTA SOLUTION PROMOTE BETTER CHELATING ACTIVITY COMPARED TO CHITOSAN OF ENDODONTIC TREATMENT? A SYSTEMATIC REVIEW AND META-ANALYSIS

• Published in: Revista de Ciências da Saúde Nova Esperança Vol. 23; no. 1; pp. 105 - 119
• Main Authors: Farias, Isabela Alcântara, Rodrigues, Matheus de Andrade, Moura, Helene Soares, Lima, Larissa Chaves Morais de, Carvalho, Morgana Maria Souza Gadêlha de, Lins, Rodrigo Barros Esteves
• Format: Journal Article
• Language: English
• Published: 30.04.2025
• ISSN: 1679-1983; 2317-7160
• DOI: 10.17695/rcsne.vol23.n1.p105-119

This systematic review and meta-analysis (MA) aimed to compare the efficacy between ethylenediaminetetraacetic acid (EDTA) (15-17%) and chitosan (CH) (0,04-1%) solution in the final irrigation of endodontic treatment in in vitro studies. The electronic search was performed on six scientific platforms, using MeSH terms, supplementary concepts, and keywords. The PICOS search strategy was: Population (P): human teeth submitted to endodontic treatment; Intervention (I): EDTA-based irrigating solution; Comparison (C): CH solution; Outcome (O): level of chelating activity; and Study design-S: in vitro studies. The risk of bias was assessed in 14 parameters and the MA by the RevMan Software. According to a random effect model, the mean, standard deviation, and total samples were used to calculate the mean and standard difference at a 95% confidence interval. The Index I² assessed heterogeneity. 22 studies of the 2,568 articles were evaluated, 7 of which were submitted to MA. The risk of bias was considered low. Three MAs evaluated the concentration of calcium ions, cement penetration into the dentinal tubules, and Knoop microhardness with no significant differences. Final irrigation of endodontic treatment with EDTA solution has a chelating activity similar to CH, based on in vitro studies with a low risk of bias.