抗菌肽LL-37在银屑病发病机制中的作用

银屑病是一种以T淋巴细胞异常活化和浸润为主要特征的慢性炎性反应皮肤病。抗菌肽LL-37的表达在银屑病的发病机制中可能处于上游地位，并成为新的治疗靶标。LL-37过度表达可导致浆细胞样树突状细胞异常活化，并激活Th1，Th17细胞与角质形成细胞间的循环刺激网络，是银屑病皮损炎症反应持续存在的重要基础。...

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Published in中国皮肤性病学杂志 Vol. 30; no. 7; pp. 748 - 750
Main Author 谢湘江 赵京霞 底婷婷 王燕 李萍
Format Journal Article
LanguageChinese
Published 2016
Subjects
LL-37
抗菌肽
银屑病
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ISSN1001-7089

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Summary:银屑病是一种以T淋巴细胞异常活化和浸润为主要特征的慢性炎性反应皮肤病。抗菌肽LL-37的表达在银屑病的发病机制中可能处于上游地位，并成为新的治疗靶标。LL-37过度表达可导致浆细胞样树突状细胞异常活化，并激活Th1，Th17细胞与角质形成细胞间的循环刺激网络，是银屑病皮损炎症反应持续存在的重要基础。
Bibliography:LL-37 ; Cathelieidin ; Psoriasis
Psoriasis is a chronic inflammatory skin disease characterized by abnormal activated T cells infiltration. Recently, LL-37 has been recognized as an upper position and potential therapeutic target in psoriasis. Overexpression of LL- 37 in psoriasis leads to abnormal activation of plasmacytoid dendritic cells and the formation of stimulation loop between Th cells （ Thl and Th17 cells） and kerotinocyte. This is one of important foundations of persist out inflammation in psoriasis lesions.
XIE Xiang-jiang, ZHAO Jing-xia, DI Ting-ting, WANG Yan, LI Ping（ 1. Beijing University of Chinese Medicine, Belting 100010, China;2. Belting Key Laboratory of Clinic and Basic Research with Traditional Chinese Medicine on Psoriasis, Beijing 100010, China; 3. Beijing Institute of Traditional Chinese Medicine, Beijing 100010, China; 4. Belting Hospital of Traditional Chinese Medicine, Affiliated with Capital Medical University,Beijing 100010, China）
61-1197/R
ISSN:1001-7089