Akt介导的信号通路在肿瘤淋巴管生成中的作用

肿瘤淋巴管生成不但为肿瘤的生长代谢提供营养物质,同时也是肿瘤淋巴结转移的重要条件。但是肿瘤淋巴管新生的分子机制十分复杂,需要多种生长因子、受体和信号通路的调控。Akt处于多条信号通路的重要交叉点,激活的Akt在肿瘤侵袭转移中具有十分重要的意义。血管内皮生长因子（vascular endothelial growth factor,VEGF）,成纤维细胞生长因子-2（fibroblast growth factor-2,FGF-2）、胰岛素样生长因子（insulin-like growth factor,IGF）、肝细胞生长因子（hepatocyte growth factor,HGF）等分子对...

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Bibliographic Details
Published in肿瘤防治研究 Vol. 43; no. 5; pp. 422 - 426
Main Author 赵静静 戴小军 张晓春
Format Journal Article
LanguageChinese
Published 2016
Subjects
Akt
成纤维细胞生长因子
淋巴管生成
肝细胞生长因子
胰岛素样生长因子
血管内皮生长因子
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ISSN1000-8578

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Summary:肿瘤淋巴管生成不但为肿瘤的生长代谢提供营养物质,同时也是肿瘤淋巴结转移的重要条件。但是肿瘤淋巴管新生的分子机制十分复杂,需要多种生长因子、受体和信号通路的调控。Akt处于多条信号通路的重要交叉点,激活的Akt在肿瘤侵袭转移中具有十分重要的意义。血管内皮生长因子（vascular endothelial growth factor,VEGF）,成纤维细胞生长因子-2（fibroblast growth factor-2,FGF-2）、胰岛素样生长因子（insulin-like growth factor,IGF）、肝细胞生长因子（hepatocyte growth factor,HGF）等分子对淋巴管生成的促进作用都是直接或间接地通过Akt信号通路介导来实现的。
Bibliography:42-1241/R
ZHAO Jingjing, DAI Xiaojun, ZHANG Xiaochun（ The First College of Clinical Medicine, A/anjing unlversuy oj ,rau,,,u Medicine, Nanjing 210029, China; 2. Department of Oncology, Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou 225002, China; 3. Yangzhou University, Yangzhou 225002, China）
Lymphangiogenesis; Akt; Vascular endothelial growth factor（VEGF）; Fibroblast growth factor-2（FGF-2）; Insulin-like growth factor（IGF）; Hepatocyte growth factor（HGF）
Tumor lymphangiogenesis not only provides nutrients for the growth of tumor metabolism, but also is the important condition of tumor lymph node metastasis. But the molecular mechanism of tumor lymphatic freshman is complex,and needs the regulation of a variety of growth factors,receptors and signaling pathways.Akt is in the important intersection of multiple signaling pathways, and the activation of Akt is of great significance in the invasion and metastasis of tumor.The molecules, such as vascular endothelial growth factor（VEGF）, fibroblast growth
ISSN:1000-8578