外周血单核细胞中HBVcccDNA检测的意义及进展

HBV在复制过程中存在着共价闭合环状DNA（cccDNA）形式，cccDNA是HBV复制的原始模板，是HBV持续感染的主要原因，也是HBV一个重要生物活性指标。HBV是嗜肝病毒，但可能存在肝外感染，有研究表明，外周血单核细胞（PBMC）中可以检测到HBV cccDNA。归纳了PBMC中HBV cccDNA在乙型肝炎患者肝移植术后及抗病毒治疗后HBV复发、HBV母婴传播中的预测作用，以及其参与HBV肝外感染的可能机制。由此可见，PBMC HBV cccDNA在HBV的治疗及研究中有重要意义。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 30; no. 8; pp. 819 - 821
Main Author 蔡少平 刘泽 徐东平
Format Journal Article
LanguageChinese
Published 2014
Subjects
DNA
乙型
单核细胞
环状
肝炎病毒
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ISSN1001-5256

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Summary:HBV在复制过程中存在着共价闭合环状DNA（cccDNA）形式，cccDNA是HBV复制的原始模板，是HBV持续感染的主要原因，也是HBV一个重要生物活性指标。HBV是嗜肝病毒，但可能存在肝外感染，有研究表明，外周血单核细胞（PBMC）中可以检测到HBV cccDNA。归纳了PBMC中HBV cccDNA在乙型肝炎患者肝移植术后及抗病毒治疗后HBV复发、HBV母婴传播中的预测作用，以及其参与HBV肝外感染的可能机制。由此可见，PBMC HBV cccDNA在HBV的治疗及研究中有重要意义。
Bibliography:CAI Shaoping, LIU Ze, XU Dongping. （ Chinese PLA Medical School, Beifing 100854, China）
hepatitis B virus ; DNA, circular; monocytes
epatitis B virus （HBV）covalently closed circular DNA （cccDNA）is an intermediate replicative episome which is stable and not easy to eliminate.cccDNA serves as the template for HBV replication and plays an important role in persistence of HBV infection in hep-atocytes,and it is also a biomarker of HBV activity.Studies suggested that HBV has extrahepatic infectivity and cccDNA could be detected in peripheral blood mononuclear cells （PBMC）.The predictive values of HBV cccDNA in PBMC for HBV recurrence after liver transplanta-tion and antiviral therapy and mother-to -child transmission of HBV in patients with hepatitis B,as well as the possible mechanism of cccDNA involved in extrahepatic HBV infection,are summarized.Therefore,the detection of HBV cccDNA is of great significance for the study and treatment of HBV.
22-1108/R
ISSN:1001-5256