Focal Cerebral Ischemia Induces Alzheimer s Disease-like Pathological Change in Rats

The changes in the tau protein phosphorylation and expression of bcl-2,and bax in rat parietal cortex neurons after focal cerebral ischemia-reperfusion(I/R)were explored,and the relationship between the tau protein phosphorylation and the expression of bax or apoptosis was clarified in order to eluc...

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Published inJournal of Huazhong University of Science and Technology. Medical sciences no. 1
Main Author 王海均 赵洪洋 叶佑范 熊南翔 黄俊红 姚东晓 沈寅 赵心同
Format Journal Article
LanguageEnglish
Published 2010
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ISSN1672-0733
1993-1352

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Summary:The changes in the tau protein phosphorylation and expression of bcl-2,and bax in rat parietal cortex neurons after focal cerebral ischemia-reperfusion(I/R)were explored,and the relationship between the tau protein phosphorylation and the expression of bax or apoptosis was clarified in order to elucidate the relationship between cerebral infarction and Alzheimer's disease.The rat focal cerebral I/R model was induced by occlusion of the right middle cerebral artery using the intraluminal suture method.The le...
Bibliography:bcl-2
42-1679/R
cerebral ischemia; Alzheimer s disease; tau protein; phosphorylation; apoptosis; bcl-2; bax
cerebral ischemia
bax
Alzheimer s disease
apoptosis
tau protein
phosphorylation
R74
ISSN:1672-0733
1993-1352