Relationship Induced Multi-atlas Learning for Alzheimer’s Disease Diagnosis
Multi-atlas based methods using magnetic resonance imaging (MRI) have been recently proposed for automatic diagnosis of Alzheimer’s disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). However, most existing multi-atlas based methods simply average or concatenate features gen...
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Published in | Medical Computer Vision: Algorithms for Big Data pp. 24 - 33 |
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Main Authors | , , , |
Format | Book Chapter |
Language | English |
Published |
Cham
Springer International Publishing
2016
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Series | Lecture Notes in Computer Science |
Subjects | |
Online Access | Get full text |
ISBN | 3319420151 9783319420158 |
ISSN | 0302-9743 1611-3349 |
DOI | 10.1007/978-3-319-42016-5_3 |
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Summary: | Multi-atlas based methods using magnetic resonance imaging (MRI) have been recently proposed for automatic diagnosis of Alzheimer’s disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). However, most existing multi-atlas based methods simply average or concatenate features generated from multiple atlases, which ignores the important underlying structure information of multi-atlas data. In this paper, we propose a novel relationship induced multi-atlas learning (RIML) method for AD/MCI classification. Specifically, we first register each brain image onto multiple selected atlases separately, through which multiple sets of feature representations can be extracted. To exploit the structure information of data, we develop a relationship induced sparse feature selection method, by employing two regularization terms to model the relationships among atlases and among subjects. Finally, we learn a classifier based on selected features in each atlas space, followed by an ensemble classification strategy to combine multiple classifiers for making a final decision. Experimental results on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database demonstrate that our method achieves significant performance improvement for AD/MCI classification, compared with several state-of-the-art methods. |
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ISBN: | 3319420151 9783319420158 |
ISSN: | 0302-9743 1611-3349 |
DOI: | 10.1007/978-3-319-42016-5_3 |