Early Carotid Atherosclerosis and Hepatic Lipase-514 C/T Polymorphism: A Study in Hyperalphalipoproteinemic Individuals

Objective: Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and has a key role in reverse cholesterol transport and atherosclerosis. The aim of this study was to evaluate the effects of HL -514C/T polymorphism on sub-clinical and established carotid atherosclerotic in hypera...

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Published inRevista argentina de endocrinología y metabolismo Vol. 50; no. 3
Main Authors Santiago, F.D, Schreiber, Panzoldo, N.B, Nakamura, R.T, Parra, E.S, Zago, V.S, Bertholo, Castanho, V.S, Danelon, M.N, Quintão, E.C.R, de Faria, E.C
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedad Argentina de Endocrinología y Metabolismo 01.09.2013
Subjects
ENDOCRINOLOGY & METABOLISM
Hepatic Lipase -514C/T polymorphism
514C/T polimorfismo de la Lipasa Hepática
Carotid atherosclerosis
Aterosclerosis carotídea
Hyperalphalipoproteinemia
Hiperalfalipoproteinemia
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ISSN1851-3034

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Summary:Objective: Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and has a key role in reverse cholesterol transport and atherosclerosis. The aim of this study was to evaluate the effects of HL -514C/T polymorphism on sub-clinical and established carotid atherosclerotic in hyperalphalipoproteinemic and control individuals. Methods: One hundred and sixty nine asymptomatic individuals (aged 47 ± 16 years), 71 hyperalphalipopro-teinemic (Hyper-A, HDL-C = 68mg/dL) and 98 controls (CTL, HDL-C< 68mg/dL) were selected by clinical and laboratory evaluations. Lipids and lipoproteins were measured by enzymatic methods. HL activity was measured in post-heparin plasma by a radiometric assay and HL-514C/T genotypes were analyzed by PCR. Carotid intima-media thickness (cIMT) was measured by Doppler ultrasonography. Results: No differences in HL -514C/T genotype frequencies were observed between the groups. HL -514C/T polymorphism did not contribute to variations in cIMT or atherosclerotic lesion frequencies in Hyper-A and controls. Furthermore, no interactions between HL-514C/T polymorphism and cIMT or atherosclerotic lesions were found. Conclusions: In hyperalphalipoproteinemic individuals the -514C/T polymorphism is not associated with significant variations in HDL-Cholesterol concentrations. Besides, it has no repercussions on carotid atherosclerosis, although hepatic lipase activity is significantly reduced. No financial conflicts of interest exist.
ISSN:1851-3034