铁皮石斛中性多糖的分离纯化及抗炎作用

TS201.4; 目的:从铁皮石斛中分离纯化得到铁皮石斛多糖,对其进行结构表征,并探究其抗炎作用.方法:以铁皮石斛为原料,通过水提醇沉法得到铁皮石斛粗多糖,再经过DEAE-52纤维素离子交换树脂和葡聚糖凝胶Sephadex G-100从粗多糖中分离纯化得到多糖组分DOP-1.利用紫外扫描法、气相色谱法、高效凝胶色谱、红外光谱和核磁共振扫描等技术对多糖DOP-1进行结构分析,并测定DOP-1对小鼠腹腔巨噬细胞RAW 264.7细胞增殖抑制效果,及其对 LPS诱导的 RAW264.7细胞 NO、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白介素-1β(inter...

Full description

Saved in:
Bibliographic Details
Published in食品工业科技 Vol. 45; no. 8; pp. 39 - 46
Main Authors 林晓亮, 谢玲娜, 陈梦香, 梁明, 梁逸恒, 杜志云
Format Journal Article
LanguageChinese
Published 无限极(中国)有限公司,广东广州 510623%广东工业大学生物医药学院,广东广州 510006 01.04.2024
Subjects
Online AccessGet full text
ISSN1002-0306
DOI10.13386/j.issn1002-0306.2023080137

Cover

Abstract TS201.4; 目的:从铁皮石斛中分离纯化得到铁皮石斛多糖,对其进行结构表征,并探究其抗炎作用.方法:以铁皮石斛为原料,通过水提醇沉法得到铁皮石斛粗多糖,再经过DEAE-52纤维素离子交换树脂和葡聚糖凝胶Sephadex G-100从粗多糖中分离纯化得到多糖组分DOP-1.利用紫外扫描法、气相色谱法、高效凝胶色谱、红外光谱和核磁共振扫描等技术对多糖DOP-1进行结构分析,并测定DOP-1对小鼠腹腔巨噬细胞RAW 264.7细胞增殖抑制效果,及其对 LPS诱导的 RAW264.7细胞 NO、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白介素-1β(interleukin-1β,IL-1β)表达的影响.结果:分离纯化得到的多糖DOP-1为鼠李糖、甘露糖、葡萄糖和半乳糖组成的均一性多糖,单糖摩尔比为 0.6∶9.0∶2.7∶2.9,分子量为 59.2 kDa.DOP-1对RAW 264.7细胞增殖无显著性抑制,与模型组相比,DOP-1能显著抑制NO、TNF-α和IL-1β的表达量.结论:本实验得到的铁皮石斛多糖结构明确,且具有较好的抗炎活性,提取工艺条件具有可行性.本研究可为铁皮石斛多糖在抗炎功效产品的开发利用提供理论依据.
AbstractList TS201.4; 目的:从铁皮石斛中分离纯化得到铁皮石斛多糖,对其进行结构表征,并探究其抗炎作用.方法:以铁皮石斛为原料,通过水提醇沉法得到铁皮石斛粗多糖,再经过DEAE-52纤维素离子交换树脂和葡聚糖凝胶Sephadex G-100从粗多糖中分离纯化得到多糖组分DOP-1.利用紫外扫描法、气相色谱法、高效凝胶色谱、红外光谱和核磁共振扫描等技术对多糖DOP-1进行结构分析,并测定DOP-1对小鼠腹腔巨噬细胞RAW 264.7细胞增殖抑制效果,及其对 LPS诱导的 RAW264.7细胞 NO、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和白介素-1β(interleukin-1β,IL-1β)表达的影响.结果:分离纯化得到的多糖DOP-1为鼠李糖、甘露糖、葡萄糖和半乳糖组成的均一性多糖,单糖摩尔比为 0.6∶9.0∶2.7∶2.9,分子量为 59.2 kDa.DOP-1对RAW 264.7细胞增殖无显著性抑制,与模型组相比,DOP-1能显著抑制NO、TNF-α和IL-1β的表达量.结论:本实验得到的铁皮石斛多糖结构明确,且具有较好的抗炎活性,提取工艺条件具有可行性.本研究可为铁皮石斛多糖在抗炎功效产品的开发利用提供理论依据.
Abstract_FL Objective:To isolate and purify polysaccharides from Dendrobium officinale,characterize their structure and explore their anti-inflammatory effects.Methods:Polysaccharides from Dendrobium officinale were obtained by water extraction and alcohol precipitation.DOP-1 was purified by DEAE-52 cellulose ion exchange resin and Sephadex G-100.Ultraviolet scanning,GC,high-performance gel chromatography,infrared spectroscopy and nuclear magnetic resonance scanning were used to analyze the structure of DOP-1 polysaccharide,and the inhibitory effect of DOP-1 on the proliferation of RAW 264.7 cells was determined.And its effect on the expression of NO,TNF-α and IL-1β in RAW264.7 cells induced by LPS.Results:DOP-1 was a homogeneous polysaccharide composed of rhamnose,mannose,glucose and galactose with a monosaccharide molar ratio of 0.6∶9.0∶2.7∶2.9 and a molecular weight of 59.2 kDa.DOP-1 did not significantly inhibit the proliferation of RAW 264.7 cells.Compared with the model group,DOP-1 significantly inhibited the expression of NO,TNF-α and IL-1β.Conclusions:The polysaccharides of Dendrobium officinaleobtained in this study had clear structure and good anti-inflammatory activity,and the extraction conditions were feasible.This study would provide theoretical basis for the development and utilization of polysaccharides of Dendrobium officinale with anti-inflammatory effect.
Author 谢玲娜
梁明
梁逸恒
杜志云
陈梦香
林晓亮
AuthorAffiliation 无限极(中国)有限公司,广东广州 510623%广东工业大学生物医药学院,广东广州 510006
AuthorAffiliation_xml – name: 无限极(中国)有限公司,广东广州 510623%广东工业大学生物医药学院,广东广州 510006
Author_FL LIN Xiaoliang
CHEN Mengxiang
XIE Lingna
LIANG Ming
DU Zhiyun
LIANG Yiheng
Author_FL_xml – sequence: 1
  fullname: LIN Xiaoliang
– sequence: 2
  fullname: XIE Lingna
– sequence: 3
  fullname: CHEN Mengxiang
– sequence: 4
  fullname: LIANG Ming
– sequence: 5
  fullname: LIANG Yiheng
– sequence: 6
  fullname: DU Zhiyun
Author_xml – sequence: 1
  fullname: 林晓亮
– sequence: 2
  fullname: 谢玲娜
– sequence: 3
  fullname: 陈梦香
– sequence: 4
  fullname: 梁明
– sequence: 5
  fullname: 梁逸恒
– sequence: 6
  fullname: 杜志云
BookMark eNo9jz9LAzEchjNUsNZ-CgenO39JLrlklOI_KHTRuSS9u9JTUjGIuKmISBEdlCucgouoizp0EcVv07vgt_BAcXpf3uF5eeZQzQxNjNACBh9TKvhS6g-sNRiAeECB-wQIBQGYhjVU_59nUdPagQbAGBhjtI749_Wxy1_d_aTMbqfvL-XRU_GQu0nm8tPi_Mw9frqPt-IiK65G5WjsTi6nX3fu5nkezSRqx8bNv2ygrdWVzda61-6sbbSW257FQJinlZYBYaGGSPKqxEkEvMcTGcRY0agXCy0VUzhQAoQmYUh5xAUPIykZJZLQBlr85R4okyjT76bD_T1TPXbtbv9wO600g0oTGP0BdNBeGA
ClassificationCodes TS201.4
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.13386/j.issn1002-0306.2023080137
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
DocumentTitle_FL Isolation and Purification of Polysaccharide and Anti-inflammatory Effect of Dendrobium officinale Neutral Polysaccharide
EndPage 46
ExternalDocumentID spgykj202408005
GroupedDBID -02
2B.
4A8
5XA
5XC
92H
92I
93N
ABJNI
ACGFS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CDRFL
CW9
GROUPED_DOAJ
PSX
TCJ
TGT
U1G
U5L
ID FETCH-LOGICAL-s1025-bab94257b0d96425efd06c6f94e1a3dce8b9a5a14a808b27736d6867d99532923
ISSN 1002-0306
IngestDate Thu May 29 04:11:23 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords neutral polysaccharide
isolation and purification
抗炎作用
structural analysis
Dendrobium officinale
中性多糖
anti-inflammatory effect
分离纯化
铁皮石斛
结构分析
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1025-bab94257b0d96425efd06c6f94e1a3dce8b9a5a14a808b27736d6867d99532923
PageCount 8
ParticipantIDs wanfang_journals_spgykj202408005
PublicationCentury 2000
PublicationDate 2024-04-01
PublicationDateYYYYMMDD 2024-04-01
PublicationDate_xml – month: 04
  year: 2024
  text: 2024-04-01
  day: 01
PublicationDecade 2020
PublicationTitle 食品工业科技
PublicationTitle_FL Science and Technology of Food Industry
PublicationYear 2024
Publisher 无限极(中国)有限公司,广东广州 510623%广东工业大学生物医药学院,广东广州 510006
Publisher_xml – name: 无限极(中国)有限公司,广东广州 510623%广东工业大学生物医药学院,广东广州 510006
SSID ssib001105553
ssib051376492
ssj0050115
Score 2.379426
Snippet TS201.4; 目的:从铁皮石斛中分离纯化得到铁皮石斛多糖,对其进行结构表征,并探究其抗炎作用.方法:以铁皮石斛为原料,通过水提醇沉法得到铁皮石斛粗多糖,再经过DEAE-52纤维素...
SourceID wanfang
SourceType Aggregation Database
StartPage 39
Title 铁皮石斛中性多糖的分离纯化及抗炎作用
URI https://d.wanfangdata.com.cn/periodical/spgykj202408005
Volume 45
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  issn: 1002-0306
  databaseCode: DOA
  dateStart: 20210101
  customDbUrl:
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: https://www.doaj.org/
  omitProxy: true
  ssIdentifier: ssj0050115
  providerName: Directory of Open Access Journals
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pa9RAFB5KBdGDqFX8TUHnJFuTSWYyc0x2sxRBTy30VjKbbKXCVmx7sCcVESmiB6VCFbyIelEPvYjif9Nt8L_wvbfT3aFarMIShsk3b773XjbzZjJ5YexKGFW2G0SdhtChasRhWTRsXJaNsJSlhQvIWtpVeeOmmp6Nr8_JubHxCW_X0uqKneqs_fG9kv_xKtSBX_Et2X_w7FAoVEAZ_AtH8DAcD-RjnhtuIggGeZ5wk_I0p0KbZxHPFTfwy3ge80zztIU1OuBpwnPJ0xjxAAYkwAbNdYyntOaaalLFs4wwILlNp5oEhkKb65QEptwkiNGC65z6anHTJIExT7Uf-yLbNEJ6IMHRljyDjqQjOaAEDE3ohOvh0xRSKKfeoEB6YyNUegTRPAMNBRHKeSZIVZDbHEEMNgYdQQoAQUdkhRL9juCMJgoGjJH7KyPC31CD1zKhgHTgRJvAMQUBQnvWl-gMsI4wBGhybbwmYFOg2nTGhSaCypnhWXvXOn4NGc7kV-FmpzArhtwHvce65Hl3CbRIe3IU-iRBQqlxfkbPg-4t53kHJrpgnIOTCwLljXs4MOL00R8YB3k-3Q1Ae6PcIP2Ui5cGK8i_jcRRRE8GF0n-UPyUwDmvxjyXowBkuC10-c7CvduLgtLuUWLiQwLG6sBbKKEgH7_pOgoyJchSsRkmjZM4yaE9Dq7Pw-zyLqFr-9Ohl_Z63aK34MWXM8fZMTcxnEwH__ITbGzt1kl21EsXOsHUzxcP6s3P9dutnY3X218_7dz_0H-3WW9t1JuP-k8e1--_19--9J9u9J-v76y_qh8-2_7xpn758RSbbeczzemG--5JYznEr0vbwhocSm1QGgWFqlsGqqO6Jq7CIio7lbamkEUYFzrQViRJpEqlVVIaIyMBM7bTbLy31KvOsElaIDCqm0S6ihPdsUJLWeoq6MiuqsrqLJt0Ws-7-9ry_B4vnPs75Dw7Mvr_XWDjK3dXq4sQq6_YS-S6X6fPpKM
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E9%93%81%E7%9A%AE%E7%9F%B3%E6%96%9B%E4%B8%AD%E6%80%A7%E5%A4%9A%E7%B3%96%E7%9A%84%E5%88%86%E7%A6%BB%E7%BA%AF%E5%8C%96%E5%8F%8A%E6%8A%97%E7%82%8E%E4%BD%9C%E7%94%A8&rft.jtitle=%E9%A3%9F%E5%93%81%E5%B7%A5%E4%B8%9A%E7%A7%91%E6%8A%80&rft.au=%E6%9E%97%E6%99%93%E4%BA%AE&rft.au=%E8%B0%A2%E7%8E%B2%E5%A8%9C&rft.au=%E9%99%88%E6%A2%A6%E9%A6%99&rft.au=%E6%A2%81%E6%98%8E&rft.date=2024-04-01&rft.pub=%E6%97%A0%E9%99%90%E6%9E%81%28%E4%B8%AD%E5%9B%BD%29%E6%9C%89%E9%99%90%E5%85%AC%E5%8F%B8%2C%E5%B9%BF%E4%B8%9C%E5%B9%BF%E5%B7%9E+510623%25%E5%B9%BF%E4%B8%9C%E5%B7%A5%E4%B8%9A%E5%A4%A7%E5%AD%A6%E7%94%9F%E7%89%A9%E5%8C%BB%E8%8D%AF%E5%AD%A6%E9%99%A2%2C%E5%B9%BF%E4%B8%9C%E5%B9%BF%E5%B7%9E+510006&rft.issn=1002-0306&rft.volume=45&rft.issue=8&rft.spage=39&rft.epage=46&rft_id=info:doi/10.13386%2Fj.issn1002-0306.2023080137&rft.externalDocID=spgykj202408005
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fspgykj%2Fspgykj.jpg