药食同源物质防治阿尔茨海默病作用机制的研究进展

TS201.4; 阿尔茨海默病(Alzheimer's disease,AD)是一种起病隐匿、进行性发展的神经退行性疾病,常见于老年群体且发病率逐年升高,目前仍没有有效的治疗手段.药食同源物质是指既是食品又是中药材的物质,因其安全性和良好的治疗保健效果,受到了广泛的关注.本文阐述了 AD的发病机制,从减缓β-淀粉样蛋白沉积、抑制Tau蛋白过度磷酸化、改善胆碱能系统、抗氧化、抗炎和保护神经元和突触等方面总结了药食同源物质抗AD的作用机制,为药食同源物质产品的开发与应用提供参考....

Full description

Saved in:
Bibliographic Details
Published in食品工业科技 Vol. 45; no. 12; pp. 18 - 27
Main Authors 康瑶, 唐瑗, 张东星, 王磊, 王鑫, 苏子孟, 於洪建
Format Journal Article
LanguageChinese
Published 天津中医药大学中药学院,天津 301617%天津益倍生物集团有限公司,天津 300457 2024
Subjects
阿尔茨海默病
药食同源物质
medicinal and edible homologous substances
mechanism
Alzheimer's disease
作用机制
Online AccessGet full text
ISSN1002-0306
DOI10.13386/j.issn1002-0306.2023090179

Cover

Abstract TS201.4; 阿尔茨海默病(Alzheimer's disease,AD)是一种起病隐匿、进行性发展的神经退行性疾病,常见于老年群体且发病率逐年升高,目前仍没有有效的治疗手段.药食同源物质是指既是食品又是中药材的物质,因其安全性和良好的治疗保健效果,受到了广泛的关注.本文阐述了 AD的发病机制,从减缓β-淀粉样蛋白沉积、抑制Tau蛋白过度磷酸化、改善胆碱能系统、抗氧化、抗炎和保护神经元和突触等方面总结了药食同源物质抗AD的作用机制,为药食同源物质产品的开发与应用提供参考.
AbstractList TS201.4; 阿尔茨海默病(Alzheimer's disease,AD)是一种起病隐匿、进行性发展的神经退行性疾病,常见于老年群体且发病率逐年升高,目前仍没有有效的治疗手段.药食同源物质是指既是食品又是中药材的物质,因其安全性和良好的治疗保健效果,受到了广泛的关注.本文阐述了 AD的发病机制,从减缓β-淀粉样蛋白沉积、抑制Tau蛋白过度磷酸化、改善胆碱能系统、抗氧化、抗炎和保护神经元和突触等方面总结了药食同源物质抗AD的作用机制,为药食同源物质产品的开发与应用提供参考.
Abstract_FL Alzheimer's disease(AD)is a progressive neurodegenerative disease with insidious onset,commonly seen in the elderly and with increasing incidence,for which there is still no effective treatment.Medicinal and edible homologous substances refer to substances that are both food and traditional Chinese medicine,and have received widespread attention due to their safety and good therapeutic and health effects.This paper describes the pathogenesis of AD,and summarizes the anti-AD mechanism of medicinal and edible homologous substances from the aspects of slowing down the deposition ofβ-amyloid,inhibiting the over-phosphorylation of Tau protein,improving the cholinergic system,antioxidant,anti-inflammatory,and protection of neurons and synapses,so as to provide references for the development and application of medicinal and edible homologous substances products.
Author 王磊
康瑶
於洪建
苏子孟
唐瑗
张东星
王鑫
AuthorAffiliation 天津中医药大学中药学院,天津 301617%天津益倍生物集团有限公司,天津 300457
AuthorAffiliation_xml – name: 天津中医药大学中药学院,天津 301617%天津益倍生物集团有限公司,天津 300457
Author_FL SU Zimeng
ZHANG Dongxing
KANG Yao
WANG Xin
YU Hongjian
WANG Lei
TANG Yuan
Author_FL_xml – sequence: 1
  fullname: KANG Yao
– sequence: 2
  fullname: TANG Yuan
– sequence: 3
  fullname: ZHANG Dongxing
– sequence: 4
  fullname: WANG Lei
– sequence: 5
  fullname: WANG Xin
– sequence: 6
  fullname: SU Zimeng
– sequence: 7
  fullname: YU Hongjian
Author_xml – sequence: 1
  fullname: 康瑶
– sequence: 2
  fullname: 唐瑗
– sequence: 3
  fullname: 张东星
– sequence: 4
  fullname: 王磊
– sequence: 5
  fullname: 王鑫
– sequence: 6
  fullname: 苏子孟
– sequence: 7
  fullname: 於洪建
BookMark eNo9j7tKA0EYhaeIYIx5Cgurjf_MP7uzW0qIFwjYaB1m3dmQKBtxELFXUIiQIsFFAwo2SaUGjZAgeRn39hYuKFYHTvGd76yQQtAJFCFrFCoU0bY22pWW1gEFYAYgWBUGDMEBKpwCKf7Xy6SsdcsFoBRM08QiqaW3L9nzY9TrxrNecjNO30dZOIkn8yxcRK_9tDuKPz6zeZjcXX1_DZP-KB7Ooutpcn-ZPPWT8TRdPERvg1Wy5Mtjrcp_WSIHW7X96o5R39verW7WDU1zH4Nblu97zBHo-eLQ4kogoLDR9kApx1bIGFLpCgkCOBdApVCucrhnm8KWnoUlsv7LPZeBL4Nmo905Ow3yxYY-aV4ctfPXnDIAxB_VXWno
ClassificationCodes TS201.4
ContentType Journal Article
Copyright Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
Copyright_xml – notice: Copyright © Wanfang Data Co. Ltd. All Rights Reserved.
DBID 2B.
4A8
92I
93N
PSX
TCJ
DOI 10.13386/j.issn1002-0306.2023090179
DatabaseName Wanfang Data Journals - Hong Kong
WANFANG Data Centre
Wanfang Data Journals
万方数据期刊 - 香港版
China Online Journals (COJ)
China Online Journals (COJ)
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
DocumentTitle_FL Research Progress on the Mechanism of Action of Medicinal and Edible Homologous Substances in the Prevention and Treatment of Alzheimer's Disease
EndPage 27
ExternalDocumentID spgykj202412003
GroupedDBID -02
2B.
4A8
5XA
5XC
92H
92I
93N
ABJNI
ACGFS
ALMA_UNASSIGNED_HOLDINGS
CCEZO
CDRFL
CW9
GROUPED_DOAJ
PSX
TCJ
TGT
U1G
U5L
ID FETCH-LOGICAL-s1023-466ffd2973df7c64e73037838d0ee98e32231ab7a07044701a7ebe94d8578ad63
ISSN 1002-0306
IngestDate Thu May 29 04:11:24 EDT 2025
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords 阿尔茨海默病
药食同源物质
medicinal and edible homologous substances
mechanism
Alzheimer's disease
作用机制
Language Chinese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-s1023-466ffd2973df7c64e73037838d0ee98e32231ab7a07044701a7ebe94d8578ad63
PageCount 10
ParticipantIDs wanfang_journals_spgykj202412003
PublicationCentury 2000
PublicationDate 2024
PublicationDateYYYYMMDD 2024-01-01
PublicationDate_xml – year: 2024
  text: 2024
PublicationDecade 2020
PublicationTitle 食品工业科技
PublicationTitle_FL Science and Technology of Food Industry
PublicationYear 2024
Publisher 天津中医药大学中药学院,天津 301617%天津益倍生物集团有限公司,天津 300457
Publisher_xml – name: 天津中医药大学中药学院,天津 301617%天津益倍生物集团有限公司,天津 300457
SSID ssib001105553
ssib051376492
ssj0050115
Score 2.3694456
Snippet TS201.4; 阿尔茨海默病(Alzheimer's disease,AD)是一种起病隐匿、进行性发展的神经退行性疾病,常见于老年群体且发病率逐年升高,目前仍没有有效的治疗手段.药食同源物质是指...
SourceID wanfang
SourceType Aggregation Database
StartPage 18
Title 药食同源物质防治阿尔茨海默病作用机制的研究进展
URI https://d.wanfangdata.com.cn/periodical/spgykj202412003
Volume 45
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAON
  databaseName: DOAJ Directory of Open Access Journals
  issn: 1002-0306
  databaseCode: DOA
  dateStart: 20210101
  customDbUrl:
  isFulltext: true
  dateEnd: 99991231
  titleUrlDefault: https://www.doaj.org/
  omitProxy: true
  ssIdentifier: ssj0050115
  providerName: Directory of Open Access Journals
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Na9RAFB9KBdGDWD_wm4LOSVI3ySSZOSbbLEXQUwu9lXxWKqzitgd7VlCo0EPFogUFL-1JLVqhRfrPuF__he-9yWZT2-IHhDA788t7L--3yXszyUwYu6VSK1ZOZht5ppQh8jw1pBMrw00TCzaVRCbOHb53352aEXdnndmR0bHKW0tLi_FEsnzkvJL_YRXqgFecJfsPzJZCoQLKwC_sgWHY_xXHPJRcTnK_wUPFfZsrKDhc1bis89DlgY_l0OMSWhWCA8F9iWAFZYswFg-CQQ0dHtS4EiS5TmDAQKWHGEACDAQqkOnwUPBgkqs61YgCDD9BL8iRINClJp9LgQVfS_bQGGwijSogpSbXX8EcJMoHz8iGhJdgcKzWK1EsigL5JuqVoKV89EJYn6ym9sCttoAR2i_QorwDx9TRyEI--RDOVzWGEDjvkMuANINRfnXQxBoOl6IsX5DTXXL6wGh_klxTJ6eX5GmwRwWocSvgKkY3AVXgGguujcNabtuYW3vcco6ywENnS01ODeVq3tDH5X9EEcYlNwWoRlMqVaEYHecg-T6plw009BhTII_3KkEPoyL2HatRUS_yObj6rUqMK-Klzpb0wg6H4rBt03PBBVJQyp-wsMerMAgM04_ypdDW4_mnDxeQLVMv4HvCwjG2yjAJpfj4RddhiumYECGFKpeMc7CLQ284FDpPspsDg-4cbw5N2WvmUXO-kl1On2Vnim7huK-v8TE2svzgHDtdWSz0PAt7rz71P75vr650dle7L7d6Xzf769ud7b3--n7781pvZbPz7Xt_b7375vnPHxvdtc3Oxm77xU737bPuh7Xu1k5v_137y-sLbKYRTtenjOIjKEYLV1UxhOvCDRS_MJfmXuKKDEKy7UlbprUsUzKDgGybUexFELuF8Gpm5MF9WYlUQiyOUte-yEabj5rZJTaeJyl0hhJXihi2vBYnjpKRE0c29JJSR1xm44UT5oqbXGvuN1Ku_BlylZ3Csh6mvMZGF58sZdchcV-MbxCTvwDUt7Da
linkProvider Directory of Open Access Journals
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E8%8D%AF%E9%A3%9F%E5%90%8C%E6%BA%90%E7%89%A9%E8%B4%A8%E9%98%B2%E6%B2%BB%E9%98%BF%E5%B0%94%E8%8C%A8%E6%B5%B7%E9%BB%98%E7%97%85%E4%BD%9C%E7%94%A8%E6%9C%BA%E5%88%B6%E7%9A%84%E7%A0%94%E7%A9%B6%E8%BF%9B%E5%B1%95&rft.jtitle=%E9%A3%9F%E5%93%81%E5%B7%A5%E4%B8%9A%E7%A7%91%E6%8A%80&rft.au=%E5%BA%B7%E7%91%B6&rft.au=%E5%94%90%E7%91%97&rft.au=%E5%BC%A0%E4%B8%9C%E6%98%9F&rft.au=%E7%8E%8B%E7%A3%8A&rft.date=2024&rft.pub=%E5%A4%A9%E6%B4%A5%E4%B8%AD%E5%8C%BB%E8%8D%AF%E5%A4%A7%E5%AD%A6%E4%B8%AD%E8%8D%AF%E5%AD%A6%E9%99%A2%2C%E5%A4%A9%E6%B4%A5+301617%25%E5%A4%A9%E6%B4%A5%E7%9B%8A%E5%80%8D%E7%94%9F%E7%89%A9%E9%9B%86%E5%9B%A2%E6%9C%89%E9%99%90%E5%85%AC%E5%8F%B8%2C%E5%A4%A9%E6%B4%A5+300457&rft.issn=1002-0306&rft.volume=45&rft.issue=12&rft.spage=18&rft.epage=27&rft_id=info:doi/10.13386%2Fj.issn1002-0306.2023090179&rft.externalDocID=spgykj202412003
thumbnail_s http://utb.summon.serialssolutions.com/2.0.0/image/custom?url=http%3A%2F%2Fwww.wanfangdata.com.cn%2Fimages%2FPeriodicalImages%2Fspgykj%2Fspgykj.jpg