体检人群保留比值受损肺功能的特点及危险因素分析
R563; 背景 保留比值受损肺功能(PRISm)是指一秒率(FEV1/FVC)正常但第一秒用力呼气容积(FEV1)减少的非阻塞性肺功能异常.PRISm人群可能是慢性阻塞性肺疾病(COPD)前期人群之一.但我国体检人群PRISm的发生率、特征及危险因素尚不清楚.目的 分析体检人群PRISm的特点及影响因素.方法 选取 2017-2019 年解放军总医院第三医学中心体检者 970 名.收集该人群一般资料、体格检查结果,测量肺功能:肺活量(VC)、用力肺活量(FVC)、FEV1、6 秒用力呼气量(FEV6)、FEV1/FVC、最大呼气流速(PEF)、呼出 25％肺活量时最大呼气流量(FEF25)、...
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| Published in | 中国全科医学 Vol. 27; no. 11; pp. 1331 - 1336 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | Chinese |
| Published |
261053 山东省潍坊市,潍坊医学院临床医学院%100039 北京市,解放军总医院第三医学中心健康医学科
15.04.2024
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1007-9572 |
| DOI | 10.12114/j.issn.1007-9572.2023.0279 |
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| Abstract | R563; 背景 保留比值受损肺功能(PRISm)是指一秒率(FEV1/FVC)正常但第一秒用力呼气容积(FEV1)减少的非阻塞性肺功能异常.PRISm人群可能是慢性阻塞性肺疾病(COPD)前期人群之一.但我国体检人群PRISm的发生率、特征及危险因素尚不清楚.目的 分析体检人群PRISm的特点及影响因素.方法 选取 2017-2019 年解放军总医院第三医学中心体检者 970 名.收集该人群一般资料、体格检查结果,测量肺功能:肺活量(VC)、用力肺活量(FVC)、FEV1、6 秒用力呼气量(FEV6)、FEV1/FVC、最大呼气流速(PEF)、呼出 25％肺活量时最大呼气流量(FEF25)、呼出 50％肺活量时最大呼气流量(FEF50)、呼出 75％肺活量时最大呼气流量(FEF75),以"％pre"表示有关指标占预计值的百分比.依据FEV1/FVC、FEV1％pre分组,即FEV1/FVC<0.7,为气流阻塞组(61 名);FEV1/FVC≥0.7,FEV1％pre<0.8,为PRISm组(111名);FEV1/FVC≥0.7,FEV1％pre≥0.8,为肺功能正常组(798名).计算体检人群中PRISm发生率,比较不同肺功能组基本特征及肺功能指标特点,采用有序Logistic回归分析探讨肺功能受损的影响因素.结果 970名体检人群中PRISm发生率为11.4％(111/970),气流阻塞发生率为6.3％(61/970).PRISm组、气流阻塞组大于 60 岁人群占比均大于肺功能正常组,41～60 岁年龄段人群占比均小于肺功能正常组(P=0.019).PRISm组吸烟者占比大于肺功能正常组(P<0.001).PRISm组人群高血压占比大于肺功能正常组(P=0.03).肺功能正常组VC％pre、FVC％pre、FEV1％pre、FEV6％pre、PEF％pre、FEF25％pre、FEF50％pre、FEF75％pre高于PRISm组、气流阻塞组(P<0.001);PRISm组VC％pre、FVC％pre、FEV6％pre、PEF％pre、FEF25％pre、FEF50％pre、FEF75％pre高于气流阻塞组(P<0.05).肺功能正常组、PRISm组FEV1/FVC高于气流阻塞组(P<0.001).以不同肺功能分组为因变量进行有序Logistic回归分析,年龄>60 岁(OR=0.951,95％CI=0.60 |
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| AbstractList | R563; 背景 保留比值受损肺功能(PRISm)是指一秒率(FEV1/FVC)正常但第一秒用力呼气容积(FEV1)减少的非阻塞性肺功能异常.PRISm人群可能是慢性阻塞性肺疾病(COPD)前期人群之一.但我国体检人群PRISm的发生率、特征及危险因素尚不清楚.目的 分析体检人群PRISm的特点及影响因素.方法 选取 2017-2019 年解放军总医院第三医学中心体检者 970 名.收集该人群一般资料、体格检查结果,测量肺功能:肺活量(VC)、用力肺活量(FVC)、FEV1、6 秒用力呼气量(FEV6)、FEV1/FVC、最大呼气流速(PEF)、呼出 25％肺活量时最大呼气流量(FEF25)、呼出 50％肺活量时最大呼气流量(FEF50)、呼出 75％肺活量时最大呼气流量(FEF75),以"％pre"表示有关指标占预计值的百分比.依据FEV1/FVC、FEV1％pre分组,即FEV1/FVC<0.7,为气流阻塞组(61 名);FEV1/FVC≥0.7,FEV1％pre<0.8,为PRISm组(111名);FEV1/FVC≥0.7,FEV1％pre≥0.8,为肺功能正常组(798名).计算体检人群中PRISm发生率,比较不同肺功能组基本特征及肺功能指标特点,采用有序Logistic回归分析探讨肺功能受损的影响因素.结果 970名体检人群中PRISm发生率为11.4％(111/970),气流阻塞发生率为6.3％(61/970).PRISm组、气流阻塞组大于 60 岁人群占比均大于肺功能正常组,41～60 岁年龄段人群占比均小于肺功能正常组(P=0.019).PRISm组吸烟者占比大于肺功能正常组(P<0.001).PRISm组人群高血压占比大于肺功能正常组(P=0.03).肺功能正常组VC％pre、FVC％pre、FEV1％pre、FEV6％pre、PEF％pre、FEF25％pre、FEF50％pre、FEF75％pre高于PRISm组、气流阻塞组(P<0.001);PRISm组VC％pre、FVC％pre、FEV6％pre、PEF％pre、FEF25％pre、FEF50％pre、FEF75％pre高于气流阻塞组(P<0.05).肺功能正常组、PRISm组FEV1/FVC高于气流阻塞组(P<0.001).以不同肺功能分组为因变量进行有序Logistic回归分析,年龄>60 岁(OR=0.951,95％CI=0.60 |
| Abstract_FL | Background Preserved Ratio Impired Spirometry(PRISm)refers to the non-obstructive pulmonary function abnormalities with a decrease forced expiratory volume in one second(FEV1)while the FEV1/forced vital capacity(FVC)remains constant.The PRISm population may be one of the pre-chronic obstructive pulmonary disease(COPD)populations.However,the incidence,characteristics and risk factors of PRISm in the physical examination population in China are still unknown.Objective To analyze the characteristics and influencing factors of PRISm in physical examination population.Methods From January 2017 to December 2019,a total of 970 patients received physical examination in the Third Medical Center of Chinese PLA General Hospital were selected.The baseline data and physical examination results were collected,pulmonary function was measured for vital capacity(VC),FVC,FEV1,forced expiratory volume in six second(FEV6),FEV1/FVC,peak expiratory flow(PEF),FEF25,FEF50 and FEF75,the relevant indexes were expressed as"％pre"as a percentage of the expected value.The included subjects were divided into the airflow obstruction group with FEV1/FVC<0.7(n=61),PRISm group with FEV1/FVC≥0.7 and FEV1％pre<0.8(n=111),normal lung function group with FEV1/FVC≥0.7 and FEV1％pre≥0.8(n=798)according to FEV1/FVC and FEV1％pre.The incidence of PRISm in physical examination population was calculated,the basic characteristics and the characteristics of lung function indexes were compared,the ordinal logistic regression analysis were used to analyze the influencing factors of lung function impairment.Results The incidence of PRISm was 11.4％and the incidence of airflow obstruction was 6.3％in 970 patients.The proportion of people over 60 years old in the PRISm group and the airflow obstruction group was higher than that the normal lung function group,and the proportion of people between 41 and 60 years old was lower than the normal lung function group(P=0.019).The proportion of smokers in the PRISm group was significantly higher than the normal lung function group(P<0.001).The proportion of patients with hypertension in the PRISm group was higher than the normal lung function group(P=0.03).VC％pre,FVC％pre,FEV1％pre,FEV6％pre,PEF％pre,FEF25％pre,FEF50％pre,FEF75％pre were higher in the normal lung function group than the PRISm group and the airflow obstruction group(P<0.001);VC％pre,FVC％pre,FEV6％pre,PEF％pre,FEF25％pre,FEF50％pre,and FEF75％pre were higher in the PRISm group than the airflow obstruction group(P<0.05).FEV1/FVC in the normal lung function group and PRISm group was higher than the airflow obstruction group(P<0.001).The ordinal logistic regression analysis with different groups of lung function as dependent variables showed that age>60 years(OR=0.951,95％CI=0.602-1.504,P=0.002),smoking history(OR=2.201,95％CI=1.519-3.187,P<0.001)and history of hypertension(OR=1.673,95％CI=1.106-3.187,P=0.015)were risk factors for lung function impairment in the physical examination population.Conclusion PRISm is common in physical examination population.Attention should be paid to the changes in lung function in those aged>60 years old,with the history of smoking and hypertension.Early intervention may alleviate the progression of COPD. |
| Author | 尚金梦 邓笑伟 |
| AuthorAffiliation | 261053 山东省潍坊市,潍坊医学院临床医学院%100039 北京市,解放军总医院第三医学中心健康医学科 |
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| Author_FL | SHANG Jinmeng DENG Xiaowei |
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| Author_xml | – sequence: 1 fullname: 尚金梦 – sequence: 2 fullname: 邓笑伟 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| Keywords | Root cause analysis 保留比值受损肺功能 Lung function 肺功能 体检人群 影响因素分析 Physical examination population PRISm 体格检查 Physical examination |
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| Title | 体检人群保留比值受损肺功能的特点及危险因素分析 |
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