Association of VDR gene polymorphism with osteoporosis in patients with chronic obstructive pulmonary disease

• Published in: Jie fang jun yi xue za zhi Vol. 44; no. 6; p. 484
• Main Authors: Kao, LI, FENG, Kai, WANG, Ping, Rui-juan, WANG, Min-li, ZHU, HU, Mei, Yue-yue, LI, Jia-ting, REN, Xiao-hui, WANG, Si-yi, TANG, Xin-yue, LIU, DONG, Jin, Ya-ya QIN, Ru-yi, YAN, Shu-jun, SONG
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 28.06.2019
• Subjects: Chronic obstructive pulmonary disease; Osteoporosis; Polymorphism; Vitamin D
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2019.06.06

Objective 　To investigate the relationship between single nucleotide polymorphism of vitamin D receptor (VDR) genes and osteoporosis in Chinese Northern Han patients with chronic obstructive pulmonary disease (COPD). Methods 　Patients with acute exacerbation COPD were enrolled and divided into osteoporosis and non-osteoporosis groups. Genomic DNA was extracted from peripheral blood of the subjects. UCSC genome browser and haploview 4.2 software were used to screen the tag single nucleotide polymorphism (tagSNPs) of VDR gene. The selected tagSNPs of VDR gene were genotyped by Sequenom MassARRAY SNP platform. Logistic regression was used to analyze the OR values and confidence intervals (CI) of each tagSNP in the codominant, dominant and recessive genetic models, and assess the relationship between single nucleotide polymorphisms in VDR gene and osteoporosis in COPD patients. Results 　A total of 379 COPD patients were enrolled. The group of osteoporosis and non-osteoporosis differed significantly in gender, age