扶正化瘀方对非酒精性脂肪性肝病大鼠肝纤维化及ACE-Ang Ⅱ-AT1R轴的影响

• Published in: Jie fang jun yi xue za zhi Vol. 43; no. 2; pp. 114 - 119
• Main Authors: Miao-miao HUO, Bian-qiao, CHENG, Wei-guo, LIN, Xu-wei, WU
• Format: Journal Article
• Language: Chinese
• Published: Beijing People's Military Medical Press 01.01.2018; 350007福州,厦门大学附属福州第二医院肝内科%350025福州,福建医科大学孟超肝胆医院肝病消化科
• Subjects: Drug dosages; Liver; Rodents; 非酒精性脂肪性肝病; nonalcoholic fatty liver disease; liver fibrosis; Fuzhenghuayu decoction; 扶正化瘀方; 肝纤维化; 肾素-血管紧张素系统; Renin-angiotensin system
• ISSN: 0577-7402
• DOI: 10.11855/j.issn.0577-7402.2018.02.05

Objective To evaluate the influence of Fuzhenghuayu decoction on fibrotic liver tissue and angiotensin- converting enzyme- angiotensin Ⅱ- angiotensin Ⅱ 1 receptor (ACE-Ang Ⅱ-AT1R) axis using a nonalcoholic fatty liver fibrosis rat model system. Methods Forty male Sprague-Dawley (SD) rats were randomly divided into the following groups: normal control group, liver fibrosis model group, and liver fibrosis model Fuzhenghuayu drug intervention at low-dose [0.75g/(kg.d)] group and high-dose [1.5g/(kg.d)] group. Except the normal control group, the other three groups were fed high-fat diet for 24 weeks to induce nonalcoholic hepatic fibrosis model. The drug intervention was administered via oral-gastric irrigation once daily for 6 times per week over a 6-week period. The rats were sacrificed at the end of 6 weeks for serum and liver tissue collection. The levels of serum total cholesterol (TC), triglycerides (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST) were measured by standard biochemical